Difference between revisions of "Transcription factors and their control"

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Transcription factors control gene expression by regulating transcription initiation or transcription elongation. Transcription initiation is regulated by DNA-binding proteins, whereas transcription elongation can be controlled by DNA-binding proteins ("transcriptional roadblocks") or RNA-binding proteins (transcription termination/ antitermination).
  
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==Reviews==
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Transcription factors can be grouped according to their mode of interaction with nucleic acids (DNA-or RNA-binding proteins) and also according to the mechanism by which they perceive the signal.
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<pubmed>18599813 </pubmed>
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=DNA-binding transcription factors=
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* [[transcription factors activating transcription at SigL-dependent promoters]]
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* [[transcription factors of the DeoR family]]
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* [[transcription factors of the GntR family]]
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* [[transcription factors of the LacI family]]
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* [[transcription factors of the LysR family]]
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* [[transcription factors of the MarR/DUF24 family]]
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* [[transcription factors of the MerR family]]
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=RNA-binding transcription factors=
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* [[transcription antiterminators]]
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* [[transcription termination proteins]]
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=Transcription factors according to signal perception=
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* [[PRD-containing transcription factors]]
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* [[transcription factors modulated by trigger enzymes]]
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* [[two-component systems]]
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=Reviews on transcription regulation=
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<pubmed> 19721087 19632156 16772031 18599813 </pubmed>
  
 
== Genes in this functional category ==
 
== Genes in this functional category ==

Revision as of 08:58, 17 January 2012

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Transcription factors control gene expression by regulating transcription initiation or transcription elongation. Transcription initiation is regulated by DNA-binding proteins, whereas transcription elongation can be controlled by DNA-binding proteins ("transcriptional roadblocks") or RNA-binding proteins (transcription termination/ antitermination).

Transcription factors can be grouped according to their mode of interaction with nucleic acids (DNA-or RNA-binding proteins) and also according to the mechanism by which they perceive the signal.

DNA-binding transcription factors

RNA-binding transcription factors

Transcription factors according to signal perception

Reviews on transcription regulation

Sacha A F T van Hijum, Marnix H Medema, Oscar P Kuipers
Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.
Microbiol Mol Biol Rev: 2009, 73(3);481-509, Table of Contents
[PubMed:19721087] [WorldCat.org] [DOI] (I p)

Sarath Chandra Janga, Ernesto Pérez-Rueda
Plasticity of transcriptional machinery in bacteria is increased by the repertoire of regulatory families.
Comput Biol Chem: 2009, 33(4);261-8
[PubMed:19632156] [WorldCat.org] [DOI] (I p)

P J Lewis, G P Doherty, J Clarke
Transcription factor dynamics.
Microbiology (Reading): 2008, 154(Pt 7);1837-1844
[PubMed:18599813] [WorldCat.org] [DOI] (P p)

Samadhi Moreno-Campuzano, Sarath Chandra Janga, Ernesto Pérez-Rueda
Identification and analysis of DNA-binding transcription factors in Bacillus subtilis and other Firmicutes--a genomic approach.
BMC Genomics: 2006, 7;147
[PubMed:16772031] [WorldCat.org] [DOI] (I e)


Genes in this functional category

Two-component system response regulators

Control of two-component response regulators

Two-component sensor kinase

Response regulator aspartate phosphatase

Control of response regulators/ other

PRD-type regulators

Control of PRD-type regulators

Transcription factors/ other

Transcription factor/ other/ based on similarity

Control of transcription factor (other than two-component system)

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