immR

168

transcriptional repressor (Xre family), controls expression of genes of the mobile genetic element ICEBs1, induction by the SOS response or the RapI-PhrI sensory system

Locus: BSU_04820

Molecular weight: 14.51 kDa

Isoelectric point: 4.99

Protein length: 127 aa

Gene length: 384 bp

Function: control of transfer of the mobile genetic element ICEBs1

Product: transcriptional repressor (Xre family)

Essential: no

Synonyms: immR, ydcN

Genomic Context

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List of homologs in different organisms, belongs to COG1396 (Galperin et al., 2021)

Gene

Coordinates: 531,130 → 531,513

The protein

Protein family

• Xre family

Domains

• HTH cro/C1-type domain (aa 7-61) (according to UniProt)

Structure

• 7T8I (PDB) PubMed
• P96631 (AlphaFold)

Effectors of protein activity

• binding of RapI to ImmR results in loss of DNA-binding activity of ImmR and subsequently in induction of ImmR-repressed genes  PubMed

Expression and Regulation

Operons

• Genes: immR-immA-int

  Description: PubMed

• Genes: immR

  Description: PubMed

Biological materials

Mutant

• BKE04820 (ΔimmR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTATCATCCATTTCA,  downstream forward: _UP4_ATTGACGAATTAAAGAAGAA
• BKK04820 (ΔimmR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTATCATCCATTTCA,  downstream forward: _UP4_ATTGACGAATTAAAGAAGAA

References

Reviews

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Original Publications

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