pyrP
168
uracil permease
locus
BSU_15480
Molecular weight
45.41 kDa
pI
9.5
function
uracil transport in/out via proton symport
product
uracil permease
essential
no
synonyms
pyrP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2233 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,619,023 1,620,330
The protein
Protein family
[wiki|xanthine/uracil permease family] (according to UniProt)
[wiki|Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily] (according to UniProt)
Structure
[PDB|3QE7] (E. coli uracil transporter, 43% identity) [pubmed|21423164]
[AF|P39766]
[wiki|Localization]
cell membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]-[gene|A5C26E10085868A0A193C450DF58D54C636B7C2D|pyrP]-[gene|B83462A50FDDD20FE9BD4681824E30AAD10F506B|pyrB]-[gene|CA16FD3507DCCADB1E01DF25B42C3405C9205B05|pyrC]-[gene|E7741ED6F15044900BDC5F0584246469D2D4D586|pyrAA]-[gene|D57DC8A53E52BC4A2EA894E3C9FD983592882918|pyrAB]-[gene|C20A05AE4CE8AEE0DA767334935CC64106A7FCCB|pyrK]-[gene|E533BEF28579CD04B24E2C728737269E35224450|pyrD]-[gene|5D0D0D2413377FCA92440334E92B5A27A5963D9E|pyrF]-[gene|0197A037D2AF049B295E1DA60187D4614B2BAC51|pyrE]
description
[Pubmed|8206849]
regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]
regulatory mechanism
[protein|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]: termination, via [wiki|RNA switch], in [regulon|protein:6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1709162], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE15480 ([gene|A5C26E10085868A0A193C450DF58D54C636B7C2D|pyrP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATGATTTCCCCCTGAT, downstream forward: _UP4_ACATCTGAACAACATCATAT
BKK15480 ([gene|A5C26E10085868A0A193C450DF58D54C636B7C2D|pyrP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATGATTTCCCCCTGAT, downstream forward: _UP4_ACATCTGAACAACATCATAT
BP1258 ([gene|A5C26E10085868A0A193C450DF58D54C636B7C2D|pyrP]::cat trp+) available in [wiki|Jörg Stülke]'s & [wiki|Fabian Commichau]'s lab
References
Page visits: 4903
Time of last update: 2025-03-11 18:39:54
Author of last update: Melvin.boenninger