tagH
168
[wiki|ABC transporter] for teichoic acid translocation ([metabolite|ATP]-binding protein)
locus
BSU_35700
Molecular weight
59.07 kDa
pI
9.45
function
[category|SW.2.6.1.3|Biosynthesis of teichoic acid]
product
[wiki|ABC transporter] for teichoic acid translocation ([metabolite|ATP]-binding protein)
essential
yes
ec
3.6.3.40
synonyms
tagH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1134 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,673,564 3,675,147
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + H2O + teichoic acid(Side 1) --> ADP + phosphate + teichoic acid(Side 2) (according to UniProt)
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 5-242) (according to UniProt)
Structure
[PDB|6JBH] (the complex corresponding to [protein|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[protein|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH] from Alicyclobacillus herbarius, corresponds to aa 1 ... 262, 54.4% identity) [pubmed|32184247]
[AF|P42954]
[wiki|Localization]
membrane associated (via [protein|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]) [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]-[gene|88028A5F3520CB6DAB014412974EB59CC5D226DD|tagE]-[gene|E730E41546298960A4B907FCB7F36C495AA9602B|tagF]-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]
description
[Pubmed|22383849]
regulation
repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: repression, [Pubmed|9457886], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: activation, [Pubmed|12950927], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7581998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
GFP fusion
3110 [gene|0467447B10EE7C1FDF86022AB6FBDBABFD32A9E5|trpC]2 [gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]::pSG5050 (cat Pxyl-gfp-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]1-648) [pubmed|18156271], available in [wiki|Dirk Jan Scheffers]' lab and in the [http://bgsc.org BGSC]
References
Reviews
Original Publications
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Time of last update: 2025-10-26 18:56:39
Author of last update: Jstuelk