fabHB
168
beta-ketoacyl-acyl carrier protein synthase III
locus
BSU_10170
Molecular weight
35.27 kDa
pI
5.68
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein synthase III
essential
no
ec
2.3.1.180
synonyms
fabHB, yhfB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0332 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,092,770 → 1,093,747
The protein
Catalyzed reaction/ biological activity
acetyl-CoA + H+ + malonyl-[ACP] --> 3-oxobutanoyl-[ACP] + CO2 + CoA (according to UniProt)
Protein family
[wiki|thiolase-like superfamily] (according to UniProt)
Structure
[PDB|8VDB] [Pubmed|38310992]
[AF|O07600]
Paralogous protein(s)
[protein|40E064365588CFED483FBFED02BFC0DA531CCC4A|fabHA], one of the two proteins has to be present for viability [Pubmed|17114254]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis [Pubmed|19820084]
Expression and Regulation
Operons
genes
[gene|FC818B3A8A3080231C1F8DE95377325C8E754DCE|fabHB]
description
[Pubmed|12737802]
regulation
induced if the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
Biological materials
Mutant
BKE10170 (Δ[gene|FC818B3A8A3080231C1F8DE95377325C8E754DCE|fabHB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGAATCACTCCTTATG, downstream forward: _UP4_TAACAAAAAAAGAACTTGTT
BKK10170 (Δ[gene|FC818B3A8A3080231C1F8DE95377325C8E754DCE|fabHB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGAATCACTCCTTATG, downstream forward: _UP4_TAACAAAAAAAGAACTTGTT
References
Reviews
Original Publications
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Time of last update: 2025-10-29 23:14:48
Author of last update: Jstuelk