Essential genes

Parent category	6. Groups of genes
Neighbouring categories	6.1. Essential genes 6.2. Membrane proteins 6.3. GTP-binding proteins 6.4. Phosphoproteins 6.5. Universally conserved proteins 6.6. Poorly characterized/ putative enzymes 6.7. Proteins of unknown function 6.8. Short peptides 6.9. ncRNA 6.10. Pseudogenes
Related categories	none
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

Protein synthesis, secretion and quality control

Aminoacyl-tRNA synthetases

• alaS
• argS
• asnS
• aspS
• cysS
• gatA
• gatB
• gatC
• gltX
• glyQ
• glyS
• hisS
• ileS
• leuS
• lysS
• metS
• pheS
• pheT
• proS
• serS
• trpS
• tyrS
• valS

Ribosomal proteins

• rplB
• rplC
• rplD
• rplE
• rplF
• rplJ
• rplL
• rplM
• rplN
• rplP
• rplQ
• rplR
• rplS
• rplT
• rplU
• rplX
• rpmA
• rpmD
• rpsB
• rpsC
• rpsD
• rpsE
• rpsG
• rpsH
• rpsI
• rpsJ
• rpsK
• rpsL
• rpsM
• rpsN
• rpsO
• rpsP
• rpsQ
• rpsR
• rpsS

Ribosome assembly

• engA
• era
• obg

rRNA modification/maturation

• cspR

tRNA modification/maturation

• tilS
• rnpA
• rnz
• cca
• fmt
• folD
• gcp

Translation factors

• frr
• fusA
• infA
• infB
• infC
• prfA
• prfB
• tsf
• tufA

Translation/ other

• map

Protein secretion/ chaperones

• ffh
• groEL
• groES

Cell envelope and cell division

Cell wall synthesis

• alr
• asd
• dapA
• dapB
• dapF
• ddl
• gcaD
• glmM
• glmS
• murAA
• murB
• murC
• murD
• murE
• murF
• murG
• pbpB

Cell division

• divIB
• divIC
• ftsA
• ftsL
• ftsW
• ftsZ
• mnaA
• mraY

Cell shape

• mreB
• mreC
• mreD

Metabolism

Central energy metabolism

• odhB
• pdhA

Biosynthesis of amino acids

• glyA
• metK

Biosynthesis of lipids

• accA
• accB
• accC
• accD
• acpA
• acpS
• cdsA
• fabD
• fabF
• fabG
• gpsA
• ispC
• ispD
• ispE
• ispF
• ispG
• ispH
• pgsA
• plsC
• plsX
• plsY

Biosynthesis of nucleotides

• adk
• cmk
• gmk
• guaB
• hprT
• nrdE
• nrdF
• nrdI

Biosynthesis of cofactors

• birA
• dfrA
• dxs
• hepS
• hepT
• menA
• menB
• menC
• menD
• menE
• menH
• nadD
• nadE
• nadF

Ion homeostasis

• mrpA
• mrpB
• mrpC
• mrpD
• mrpF

Phosphate metabolism

• ppaC

DNA replication, modification, and chromosome maintenance

DNA replication

• dnaA
• dnaB
• dnaC
• dnaD
• dnaE
• dnaG
• dnaI
• dnaN
• dnaX
• holA
• holB
• ligA
• pcrA
• polC
• priA
• ssbA

Chromosome condensation/ segregation

• gyrA
• gyrB
• hbs
• parC
• parE

RNA synthesis and degradation

Transcription

• nusA
• rpoA
• rpoB
• rpoC
• sigA

RNases

• rnjA
• rny

Detoxification systems

• dgkB
• hlpB
• pncB
• rnc

Unknown

• ycgG
• yddT
• ylaN
• yomL

Other

• prs
• prsA
• pyrG
• racE
• rbgA
• resB
• resC

• rodA

• scpA
• scr
• secA
• secE
• secY

• sknR
• smc
• spoVC

• sufB
• sufC
• sufD
• sufS
• sufU
• tagB
• tagD
• tagF
• tagG
• tagH
• tagO

• tmk
• trmD
• trmU

• trxA
• trxB

• uppS

• walK
• walR

• ydiC
• ydiO
• ydiP
• yfkN
• yhdL
• ykuQ
• ykuR

• ypuF
• yqeH
• yrvO
• ysxC
• ytaG
• yumC

Important original publications

Helena B Thomaides, Ella J Davison, Lisa Burston, Hazel Johnson, David R Brown, Alison C Hunt, Jeffery Errington, Lloyd Czaplewski
Essential bacterial functions encoded by gene pairs.
J Bacteriol: 2007, 189(2);591-602
[PubMed:17114254] [WorldCat.org] [DOI] (P p)

Alison Hunt, Joy P Rawlins, Helena B Thomaides, Jeff Errington
Functional analysis of 11 putative essential genes in Bacillus subtilis.
Microbiology (Reading): 2006, 152(Pt 10);2895-2907
[PubMed:17005971] [WorldCat.org] [DOI] (P p)

K Kobayashi, S D Ehrlich, A Albertini, G Amati, K K Andersen, M Arnaud, K Asai, S Ashikaga, S Aymerich, P Bessieres, F Boland, S C Brignell, S Bron, K Bunai, J Chapuis, L C Christiansen, A Danchin, M Débarbouille, E Dervyn, E Deuerling, K Devine, S K Devine, O Dreesen, J Errington, S Fillinger, S J Foster, Y Fujita, A Galizzi, R Gardan, C Eschevins, T Fukushima, K Haga, C R Harwood, M Hecker, D Hosoya, M F Hullo, H Kakeshita, D Karamata, Y Kasahara, F Kawamura, K Koga, P Koski, R Kuwana, D Imamura, M Ishimaru, S Ishikawa, I Ishio, D Le Coq, A Masson, C Mauël, R Meima, R P Mellado, A Moir, S Moriya, E Nagakawa, H Nanamiya, S Nakai, P Nygaard, M Ogura, T Ohanan, M O'Reilly, M O'Rourke, Z Pragai, H M Pooley, G Rapoport, J P Rawlins, L A Rivas, C Rivolta, A Sadaie, Y Sadaie, M Sarvas, T Sato, H H Saxild, E Scanlan, W Schumann, J F M L Seegers, J Sekiguchi, A Sekowska, S J Séror, M Simon, P Stragier, R Studer, H Takamatsu, T Tanaka, M Takeuchi, H B Thomaides, V Vagner, J M van Dijl, K Watabe, A Wipat, H Yamamoto, M Yamamoto, Y Yamamoto, K Yamane, K Yata, K Yoshida, H Yoshikawa, U Zuber, N Ogasawara
Essential Bacillus subtilis genes.
Proc Natl Acad Sci U S A: 2003, 100(8);4678-83
[PubMed:12682299] [WorldCat.org] [DOI] (P p)