sufU

168

sulfur shuttle protein, receives sulfur from SufS, transfers it to SufB

Locus: BSU_32680

Molecular weight: 16.02 kDa

Isoelectric point: 4.71

Protein length: 147 aa

Gene length: 444 bp

Function: transfer of sulfur from SufS to SufB

Product: sulfur shuttle protein

Essential: yes

E.C.: 2.-.-.-

Synonyms: sufU, yurV, iscU

Genomic Context

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List of homologs in different organisms, belongs to COG0822 (Galperin et al., 2021)

Gene

Coordinates: 3,357,011 → 3,357,454

Phenotypes of a mutant

• essential PubMed
• the mutant is viable and Fe-S clusters are dispensable if IspG and IspH from the MEP pathway  for  isoprenoid  biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate PubMed

The protein

Catalyzed reaction/ biological activity

• transfer of sulfur from SufS to SufB PubMed

Protein family

• NifU family (with Nfu, according to UniProt)

Cofactors

• zinc PubMed

Structure

• 5XT5 (PDB) (the SufS₂-SufU₂ complex) PubMed
• 2AZH (PDB)
• O32163 (AlphaFold)

Expression and Regulation

Operons

• Genes: sufC-sufD-sufS-sufU-sufB

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-B584 (yurV::erm), available at the NBRP B. subtilis, Japan

References

Reviews

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Original Publications

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