serS

168

seryl-tRNA-synthetase

Locus: BSU_00130

Molecular weight: 48.68 kDa

Isoelectric point: 5.19

Protein length: 425 aa

Gene length: 1278 bp

Function: translation

Product: seryl-tRNA-synthetase

Essential: yes

E.C.: 6.1.1.11

Synonyms: serS

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0172 (Galperin et al., 2021)

Gene

Coordinates: 20,880  22,157

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-serine + tRNA(Ser) --> AMP + diphosphate + L-seryl-tRNA(Ser) (according to UniProt)

Protein family

• Class-II aminoacyl-tRNA synthetase family (according to UniProt)

Structure

• 6R1N (PDB) (from Staphylococcus aureus, 54.5% identity) PubMed
• P37464 (AlphaFold)

Localization

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• Genes: serS

  Description: PubMed

  Regulation

  • induced by serine limitation (T-box) PubMed

  Regulatory mechanism

  • T-box: RNA switch, in T-box

• Genes: dacA-pdxS-pdxT-serS

  Description: PubMed

  Regulation

  • the leader mRNA is processed upstream of dacA by RNase Y, this requires the RicA-RicF-RicT complex PubMed

• Genes: pdxS-pdxT-serS

  Description: PubMed

References

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