tsf

168

elongation factor Ts, nucleotide exchange factor for EF-Tu

Locus: BSU_16500

Molecular weight: 32.00 kDa

Isoelectric point: 4

Protein length: 293 aa

Gene length: 882 bp

Function: translation

Product: elongation factor Ts

Essential: yes

Synonyms: tsf

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0264 (Galperin et al., 2021)

Gene

Coordinates: 1,718,775 1,719,656

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• nucleotide exchange factor for EF-Tu PubMed

Protein family

• EF-Ts family (single member, according to UniProt)

Structure

• 1EFU (PDB) (the Tsf-TufA complex from E. coli, 50% identity) PubMed
• P80700 (AlphaFold)

Modification

• phosphorylation on Ser-149 PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: rpsB-tsf-pyrH-frr

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed

  Regulatory mechanism

  • stringent response: negative regulation, PubMed, in stringent response

References

Reviews

Loading

Original Publications

Loading