Difference between revisions of "Two-component systems"
| Line 2: | Line 2: | ||
More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of [[Spo0A]]. | More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of [[Spo0A]]. | ||
| − | ==Two-component systems in ''B. subtilis''== | + | ==Two-component systems in ''B. subtilis'' (kinase, regulator)== |
* NarL-family | * NarL-family | ||
** [[ComP]], [[ComA]] | ** [[ComP]], [[ComA]] | ||
| Line 21: | Line 21: | ||
** [[ResE]], [[ResD]] | ** [[ResE]], [[ResD]] | ||
** [[WalK]], [[WalR]]: the only essential two-component system! | ** [[WalK]], [[WalR]]: the only essential two-component system! | ||
| + | ** [[YbdK]], [[YbdJ]] | ||
| + | ** [[YcbM]], [[YcbL]] | ||
| + | ** [[YclK]], [[YclJ]] | ||
| + | ** [[YkoH]], [[YkoG]] | ||
| + | ** [[YrkO]], [[YrkP]] | ||
| + | ** [[YvcQ]], [[YvcP]] | ||
| + | ** [[YvrG]], [[YvrHb]] | ||
| + | ** [[YxdK]], [[YxdJ]] | ||
| + | |||
| + | * CheY family | ||
| + | ** [[CheA]], [[CheY]] | ||
| + | |||
| + | * DctR family | ||
| + | ** [[CitS]], [[CitT]] | ||
| + | ** [[DctS]], [[DctR]] | ||
| + | ** [[GlnK]], [[GlnL]] | ||
| + | ** [[MalK]], [[MalR]] | ||
| + | |||
| + | * LytT family | ||
| + | ** [[LytS]], [[LytT]] | ||
| + | ** [[YesM]], [[YesN]] | ||
| + | ** [[YwpD]] (orphan) | ||
| + | |||
| + | ==The phosphorelay== | ||
| + | * Kinases | ||
| + | ** [[KinA]] | ||
| + | ** [[KinB]] | ||
| + | ** [[KinC]] | ||
| + | ** [[KinD]] | ||
| + | ** [[KinE]] | ||
| + | |||
| + | * Phosphotranferases | ||
| + | ** [[Spo0F]] | ||
| + | ** [[Spo0B]] | ||
| + | |||
| + | * The ultimate target | ||
| + | ** [[Spo0A]] | ||
==Reviews== | ==Reviews== | ||
<pubmed>17338439 19575571 11406410 10966457 10932244 17158704 10094672 </pubmed> | <pubmed>17338439 19575571 11406410 10966457 10932244 17158704 10094672 </pubmed> | ||
Revision as of 22:15, 27 November 2009
Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.
Two-component systems in B. subtilis (kinase, regulator)
- NarL-family
- OmpR family
The phosphorelay
- The ultimate target
Reviews
