accD
168

acetyl-CoA carboxylase (beta subunit)

Locus

BSU_29210

Molecular weight

28.73 kDa

Isoelectric point

5.34

Protein length

290 aaSequenceBlast

Gene length

873 bpSequenceBlast

Function

production of malonyl-CoA, the substrate for fatty acid biosynthesis

Product

acetyl-CoA carboxylase (beta subunit))

Essential

yes

E.C.

6.4.1.2

Synonyms

accD, yttI

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0777 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,988,693 → 2,989,565

Phenotypes of a mutant

essential PubMed

enhanced colony wrinkling upon knockdown PubMed

Additional information

ponA ecsA, ponA sigI, and ponA rasP double mutants have a growth defect that can be suppressed by reduced fatty acid synthesis (mutations in accA, accB, accC, accD or downregulation of the FapR regulon due to specific mutations in fapR) PubMed

The protein

Catalyzed reaction/ biological activity

acetyl-CoA + N⁶-carboxybiotinyl-L-lysyl-[protein] --> malonyl-CoA + N⁶-biotinyl-L-lysyl-[protein] (according to UniProt)

Protein family

AccD/PCCB family (with YngE and YqjD, according to UniProt)

Domains

CoA carboxyltransferase N-terminal domain (aa 28-290) (according to UniProt)

Structure

2F9I (PDB) (from Staphylococcus aureus; equivalent to AccD-AccA, 64% identity) PubMed

C0SP93 (AlphaFold)

Modification

phosphorylated on Arg-205 PubMed