sweD

sweD
168

cofactor of the FtsE-FtsX complex

Locus
BSU_24930
Molecular weight
13.18 kDa
Isoelectric point
5.05
Protein length
117 aaSequenceBlast
Gene length
354 bpSequenceBlast
Function
control of CwlO activity in peptidoglycan elongation
Product
cofactor of the FtsE-FtsX complex
Essential
no
Synonyms
sweD, yqzD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
2,576,367  2,576,720
Phenotypes of a mutant
synthetically lethal with LytE, this can be suppressed by point mutations in ftsE or ftsX PubMed
cells are shorter and fatter than wild-type, cells are bent and curved, both phenotypes depend on the presence of CwlO PubMed
defective in Swarming motility (prolonged period of immotility prior to Swarming) PubMed
The protein
Structure
O32022 (AlphaFold)
Localization
cell membrane (integral), C-terminal cytoplasmic domain PubMed
Expression and Regulation
Operons
Genes
sweD-sweC
Description
PubMed
Regulation
repressed under conditions that trigger sporulation (Spo0A) PubMed
Regulatory mechanism
Spo0A: repression, PubMed, in spo0A regulon
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sweD→sweC

2025-03-15 08:29:59

Jstuelk

63

d3c26c5c0ad2b02d64f20f743f9b69d1f54de8a0

AC8611ADAB04045125A5F4EF9942EC21D42A527B

Additional information
the mRNA is cleaved by RNase III PubMed
Biological materials
Mutant
MGNA-C483 (yqzD::erm), available at the NBRP B. subtilis, Japan
BKE24930 (sweD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGTTTCATCACCTTCTAT,  downstream forward: _UP4_AAAGATAATGAGAAGGTGCT
BKK24930 (sweD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGTTTCATCACCTTCTAT,  downstream forward: _UP4_AAAGATAATGAGAAGGTGCT
References
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5F184E491602D548AAE8E6D598BB742513770F73

Page visits: 2973

Time of last update: 2025-04-15 08:40:33

Author of last update: Jstuelk