sweC
168
cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] complex
locus
BSU_24940
Molecular weight
16.88 kDa
pI
9.01
function
control of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] activity in peptidoglycan elongation
product
cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] complex
essential
no
ec
null
synonyms
sweC, yqzC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1559 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,576,717 2,577,181
Phenotypes of a mutant
synthetic lethal with [protein|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE], this can be suppressed by point mutations in [gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE] or [gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] [pubmed|31437162]
cells are shorter and fatter than wild-type, cells are bent and curved, both phenotypes depend on the presence of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [pubmed|31437162]
defective in [category|SW.4.1.4|Swarming] motility (prolonged period of immotility prior to [category|SW.4.1.4|Swarming]) [pubmed|35638827]
The protein
Structure
[AF|O32023]
[wiki|Localization]
cell membrane (integral), C-terminal cytoplasmic domain [pubmed|31437162]
Expression and Regulation
Operons
genes
[gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]-[gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]
description
[Pubmed|22383849]
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
Biological materials
Mutant
MGNA-C484 (yqzC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2482 NBRP B. subtilis, Japan]
BKE24940 ([gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT, downstream forward: _UP4_TAAAAAAACAGGCTGACTCA
BKK24940 ([gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT, downstream forward: _UP4_TAAAAAAACAGGCTGACTCA
References
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Time of last update: 2024-10-04 13:57:19
Author of last update: Jstuelk