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ftsX
168
[wiki|ABC transporter] (membrane protein) ([protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]), required for [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] activity (cell elongation) and for proper activation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A] and initiation of [wiki|sporulation]
Molecular weight
32.95 kDa
function
control of cell wall synthesis
product
[wiki|ABC transporter] (membrane protein)
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,623,938 → 3,624,828
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
a ''[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]'' mutation is synthetically lethal with a ''[gene|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE]'' mutation (due to a lack of autolysin activity) [Pubmed|23869552,23855774]
shorter, fatter cells, this can be rescued by addition of Mg(2+) [Pubmed|23869552,23855774]
the mutant cells are thicker and shorter than wild type cells [pubmed|34846166]
reduced growth rate, especially at low Mg(2+) concentrations [Pubmed|23869552]
loss of genetic competence [pubmed|29553055]
defective in [category|SW.4.1.4|Swarming] motility (periodic cessation and reinitiation of [category|SW.4.1.4|Swarming] motility, terracing colonies) [pubmed|35638827]
poor growth of a [gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS] [gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] double mutant [pubmed|39185233]
The protein
Catalyzed reaction/ biological activity
necessary for the autolysin activity of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [Pubmed|23855774]
Protein family
[wiki|ABC-4 integral membrane protein family] (according to UniProt)
Structure
[wiki|Localization]
cell membrane [Pubmed|23869552]
Expression and Regulation
Operons
genes
[gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]
description
(according to [http://dbtbs.hgc.jp/COG/prom/ftsEX.html DBTBS]) null
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
[gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]→[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]
2024-10-12 22:36:08
ghost
97
2cc5c6f6d5937ee06ba05b9f32e1806d70a64558
0160C162B03C88639486948C622D41CB46D2FE11
Biological materials
Mutant
GP3198 ([gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]::''spc''), available in [wiki|Jörg Stülke]'s lab
BKE35250 (Δ[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTCACGCAAGTGGCGCCCGA, downstream forward: _UP4_TAAAGTGAAAAAGCCGTTCC
BKK35250 (Δ[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTCACGCAAGTGGCGCCCGA, downstream forward: _UP4_TAAAGTGAAAAAGCCGTTCC
References
Reviews
Original Publications
10092453,18573177,23651456,14651647,18763711,23855774,23869552,29553055,31437162,33450852,34846166,35638827,36815589,39185233
