ftsE
168
[wiki|ABC transporter ]([metabolite|ATP]-binding protein) ([protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]), required for [protein|search|CwlO ]activity (cell elongation) and for proper activation of [protein|search|Spo0A ]and initiation of [wiki|sporulation]
locus
BSU_35260
Molecular weight
25.47 kDa
pI
8.42
function
control of [wiki|cell wall synthesis]
product
[wiki|ABC transporter ]([metabolite|ATP]-binding protein)
essential
no
synonyms
ftsE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2884 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,624,821 3,625,507
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
a ''[gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]'' mutation is synthetically lethal with a ''[gene|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE]'' mutation (due to a lack of autolysin activity) [Pubmed|23869552,23855774]
shorter, fatter cells, this can be rescued by addition of Mg(2+) [Pubmed|23869552,23855774]
the mutant cells are thicker and shorter than wild type cells [pubmed|34846166]
reduced growth rate, especially at low Mg(2+) concentrations [Pubmed|23869552]
defective in [category|SW.4.1.4|Swarming] motility (periodic cessation and reinitiation of [category|SW.4.1.4|Swarming] motility, terracing colonies) [pubmed|35638827]
poor growth of a [gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS] [gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE] double mutant [pubmed|39185233]
The protein
Catalyzed reaction/ biological activity
necessary for the autolysin activity of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [Pubmed|23855774]
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 2-227) (according to UniProt)
Structure
[PDB|3TIF] (ATP-binding protein from ''Methanococcus jannaschii'', 40% identity) [Pubmed|22158619]
[AF|O34814]
Paralogous protein(s)
[protein|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY], [protein|4FE6A51A0D9BBBF574EA2EF18B95B5BFC0A64CCB|ytrE], [protein|8B4267532B9788AEB5EF39E2695C1FDA494C7055|yxdL], [protein|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA], [protein|0F8048267EC038D8CF673317D969BA27735473A7|yvrO]
[wiki|Localization]
membrane associated (via [protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]) [Pubmed|18573177]
Expression and Regulation
Operons
genes
[gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX]
description
(according to [http://dbtbs.hgc.jp/COG/prom/ftsEX.html DBTBS]) null
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
Biological materials
Mutant
BKE35260 ([gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAAATCACCTAATCTTT, downstream forward: _UP4_GAGTCAAGAGGGGAGTATGG
BKK35260 ([gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAAATCACCTAATCTTT, downstream forward: _UP4_GAGTCAAGAGGGGAGTATGG
References
Reviews
Original Publications
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Time of last update: 2024-12-20 21:01:09
Author of last update: Jstuelk