thrC

thrC
168

threonine synthase, has a minor threonine dehydratase (IlvA) activity

Locus
BSU_32250
Molecular weight
37.31 kDa
Isoelectric point
5.18
Protein length
352 aaSequenceBlast
Gene length
1059 bpSequenceBlast
Function
biosynthesis of threonine
Product
threonine synthase
Essential
no
E.C.
4.2.3.1
Synonyms
thrC, thrB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0498 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,313,770 3,314,828
Phenotypes of a mutant
auxotrophic for threonine PubMed
The protein
Catalyzed reaction/ biological activity
O-phospho-L-homoserine + H2O --> L-threonine + phosphate (according to UniProt)
has additional threonine dehydratase activity PubMed
Protein family
threonine synthase family (single member, according to UniProt)
Cofactors
PLP
Structure
6CGQ (PDB) (complexed with PLP and PLP-Ala) PubMed
6NMX (PDB) (complexed with PLP and (Z)-L-2-amino-5-phosphono-3-pentenoic acid (APPA)) PubMed
P04990 (AlphaFold)
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
yutH-hom-thrC-thrB
Description
PubMed
Regulation
expressed during sporulation PubMed
Open in new tab

yutH→thrB

2025-04-04 08:11:12

Jstuelk

127

679308b32ee019040de1f3917a024913a4a6e24e

A05F487B4319B2D895BE22D03C7D331712EA7165

Genes
hom-thrC-thrB
Description
PubMed
Regulation
expressed in the presence of lysine or cysteine (ThrR) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
TnrA: repression, PubMed, in tnrA regulon
ThrR: repression, PubMed, in thrR regulon
Open in new tab

hom→thrB

2025-03-17 14:53:32

ghost

126

222d0d37f0abf96a1c1d52c80944e1ea90292f91

CF7B5B8FEE827A7467051420FCA74276BC912664

Biological materials
Mutant
GP3030 thrC::spc, available in Jrg Stlke's lab PubMed
1A773 (thrC::cat), PubMed, available at BGSC and in Jrg Stlke's lab
BKE32250 (thrC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTGATGGATAAGTCCTTTCC, downstream forward: _UP4_TATGTAAAAGGAGCGGCCCG
BKK32250 (thrC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTGATGGATAAGTCCTTTCC, downstream forward: _UP4_TATGTAAAAGGAGCGGCCCG
References
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4A839F8A53DF75DF01FE410EBD3361759C3B1C86

Page visits: 7172

Time of last update: 2025-04-08 09:04:52

Author of last update: Jstuelk