thrB
168
homoserine kinase
locus
BSU_32240
Molecular weight
33.17 kDa
pI
4.74
function
biosynthesis of threonine
product
homoserine kinase
essential
no
ec
2.7.1.39
synonyms
thrB, thrA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0083 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,312,844 3,313,773
The protein
Catalyzed reaction/ biological activity
ATP + L-homoserine --> ADP + H+ + O-phospho-L-homoserine (according to UniProt)
Protein family
GHMP kinase family (together with [protein|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK] and [protein|8FA635D1915108BF29A864AF4DA28ECF633F735F|ispE]) (according to UniProt)
Structure
[PDB|3HUL] (from ''Listeria monocytogenes'', 41% identity, 61% similarity)
[AF|P04948]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|0F40291BB10DB6D7DFD94B9C7D700F4410C4EE69|yutH]-[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|22383849]
regulation
expressed during [wiki|sporulation] [Pubmed|22383849]
genes
[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|12107147]
regulation
expressed in the presence of lysine or cysteine ([wiki|ThrR]) [Pubmed|27260660]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|24163341], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA]: repression, [Pubmed|25755103], in [regulon|protein:857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA regulon]
[protein|A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR]: repression, [Pubmed|27260660], in [regulon|protein:A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR regulon]
Biological materials
Mutant
BKE32240 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGAGAACAGCATGTCGGCTT, downstream forward: _UP4_TAGATCATGCCAAGCGTTCC
BKK32240 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32240 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGAGAACAGCATGTCGGCTT, downstream forward: _UP4_TAGATCATGCCAAGCGTTCC
BP1275 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::phleo trp+) available in [wiki|Jörg Stülke]'s & [wiki|Fabian Commichau]'s lab
References
Page visits: 4445
Time of last update: 2025-04-02 14:30:51
Author of last update: Melvin.boenninger