yhdL

yhdL
168

anti-[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM] factor, with [protein|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK], responds to the free pool of the carrier lipid undecaprenyl-phosphate

locus
BSU_09510
Molecular weight
40.42 kDa
pI
6.18
Protein length
Gene length
function
control of [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM] activity
product
anti-[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM] protein
essential
yes
synonyms
yhdL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
1,028,511  1,029,587
Phenotypes of a mutant
essential [Pubmed|12682299]
essentiality is suppressed by a [protein|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1] gain-of-function mutation (Q140K) present in B. subtilis strain PY97 [pubmed|31626625]
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The protein
Structure
[AF|O07581]
[wiki|Localization]
cell membrane [Pubmed|14993308]
Expression and Regulation
Operons
genes
[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]-[gene|48975EC8FB5B03F136AA112DE2ED9CFD0E9C4141|yhdL]-[gene|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK]
description
[Pubmed|9573210]
regulation
induced by glucose [Pubmed|27965645]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9573210], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|9573210,18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
additional information
expression of [protein|search|CsbB] in the absence of [protein|search|YfhO] causes constitutive activation of [protein|search|SigM] [PubMed|23632331]
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[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]→[gene|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK]

2024-05-30 13:44:37

ghost

97

fb4e4633900f4ef286077c42a3c137436842759c

3F70EAF5AFE9E64A7150341483663D9A7347A835

Biological materials
Mutant
MGNA-B482 (yhdL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1481 NBRP B. subtilis, Japan]
BP97 (Δ([gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]-[gene|48975EC8FB5B03F136AA112DE2ED9CFD0E9C4141|yhdL]-[gene|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK])::aphA3), available in [wiki|Fabian Commichau]'s lab
References
Reviews
27344142,29343670
Original Publications
18179421,14993308,10216858,26399770,30715747,31626625,38683856

48975EC8FB5B03F136AA112DE2ED9CFD0E9C4141

Page visits: 2999

Time of last update: 2024-06-20 05:56:31

Author of last update: Jstuelk