Carbon core metabolism

Parent categories	2. Metabolism 2.2. Carbon metabolism
Neighbouring categories	2.2.1. Carbon core metabolism 2.2.2. Utilization of specific carbon sources
Related categories	regulators of core metabolism CcpA regulon CcpC regulon CggR regulon
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

Glycolysis

• cggR
• eno
• fbaA
• gapA
• glcT
• mgsA
• pfkA
• pgi
• pgk
• pgm
• ptsG
• pyk
• tpi

see the structures of glycolytic enzymes Glycolytic enzymes: molecules of the month

Gluconeogenesis

• ccpN
• eno
• fbaA
• fbp
• gapB
• glpX
• pckA
• pgi
• pgk
• pgm
• tpi
• yqfL
• yvcK

Pentose phosphate pathway

• gndA
• rpe
• tkt
• ykgB
• ywjH
• ywlF
• zwf

TCA cycle

• ccpC
• citB
• citG
• citZ
• fsrA
• icd
• mdh
• odhA
• odhB
• pdhA
• pdhB
• pdhC
• pdhD
• pycA
• sdhA
• sdhB
• sdhC
• sucC
• sucD

Overflow metabolism

• ackA
• alsD
• alsR
• alsS
• bdhA
• lctP
• ldh
• pta
• rex

Important original publications

Frederik M Meyer, Jan Gerwig, Elke Hammer, Christina Herzberg, Fabian M Commichau, Uwe Völker, Jörg Stülke
Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon.
Metab Eng: 2011, 13(1);18-27
[PubMed:20933603] [WorldCat.org] [DOI] (I p)

Roelco J Kleijn, Joerg M Buescher, Ludovic Le Chat, Matthieu Jules, Stephane Aymerich, Uwe Sauer
Metabolic fluxes during strong carbon catabolite repression by malate in Bacillus subtilis.
J Biol Chem: 2010, 285(3);1587-96
[PubMed:19917605] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Fabian M Rothe, Christina Herzberg, Eva Wagner, Daniel Hellwig, Martin Lehnik-Habrink, Elke Hammer, Uwe Völker, Jörg Stülke
Novel activities of glycolytic enzymes in Bacillus subtilis: interactions with essential proteins involved in mRNA processing.
Mol Cell Proteomics: 2009, 8(6);1350-60
[PubMed:19193632] [WorldCat.org] [DOI] (I p)

Simon Tännler, Eliane Fischer, Dominique Le Coq, Thierry Doan, Emmanuel Jamet, Uwe Sauer, Stéphane Aymerich
CcpN controls central carbon fluxes in Bacillus subtilis.
J Bacteriol: 2008, 190(18);6178-87
[PubMed:18586936] [WorldCat.org] [DOI] (I p)

Anne Goelzer, Fadia Bekkal Brikci, Isabelle Martin-Verstraete, Philippe Noirot, Philippe Bessières, Stéphane Aymerich, Vincent Fromion
Reconstruction and analysis of the genetic and metabolic regulatory networks of the central metabolism of Bacillus subtilis.
BMC Syst Biol: 2008, 2;20
[PubMed:18302748] [WorldCat.org] [DOI] (I e)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)

H Ludwig, G Homuth, M Schmalisch, F M Dyka, M Hecker, J Stülke
Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon.
Mol Microbiol: 2001, 41(2);409-22
[PubMed:11489127] [WorldCat.org] [DOI] (P p)

U Sauer, V Hatzimanikatis, J E Bailey, M Hochuli, T Szyperski, K Wüthrich
Metabolic fluxes in riboflavin-producing Bacillus subtilis.
Nat Biotechnol: 1997, 15(5);448-52
[PubMed:9131624] [WorldCat.org] [DOI] (P p)