lctP

168

lactate permease, excretion

Locus: BSU_03060

Molecular weight: 57.49 kDa

Isoelectric point: 9.77

Protein length: 541 aa

Gene length: 1626 bp

Function: lactate excretion

Product: L-lactate permease

Essential: no

Synonyms: lctP, ycgC

Genomic Context

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List of homologs in different organisms, belongs to COG1620 (Galperin et al., 2021)

Gene

Coordinates: 330,771  332,396

The protein

Protein family

• lactate permease family (with LutP, according to UniProt)

Structure

• P55910 (AlphaFold)

Paralogous protein(s)

• LutP

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: ldh-lctP

  Description: PubMed

  Regulation

  • induced under anaerobic conditions (Rex) PubMed

  Regulatory mechanism

  • Rex: repression, PubMed, in rex regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE03060 (lctP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGACAATCAGCCCTTTA,  downstream forward: _UP4_TAATAGAAAAAAGCAGTACA
• BKK03060 (lctP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGACAATCAGCCCTTTA,  downstream forward: _UP4_TAATAGAAAAAAGCAGTACA
• GP2578 (lctP::tet comIQ12L) (in DK1042) available in Jörg Stülke's lab

References

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