fatR

fatR
168

transcriptional repressor of the fatR-yrhJ operon

Locus
BSU_27170
Molecular weight
22.07 kDa
Isoelectric point
5.62
Protein length
194 aaSequenceBlast
Gene length
585 bpSequenceBlast
Function
unknown
Product
transcriptional repressor of the fatR-yrhJ operon (TetR family)
Essential
no
Synonyms
fatR, yrhI, bscR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,777,070  2,777,654
The protein
Protein family
TetR family
Domains
HTH tetR-type domain (aa 6-66) (according to UniProt)
Structure
4ME9 (PDB) (from B. cereus, 38% identity)
O08335 (AlphaFold)
Modification
phosphorylated by PtkA on Tyr-45, this results in displacement of FatR from the DNA PubMed
Expression and Regulation
Operons
Genes
fatR-yrhJ
Description
PubMed
Regulation
expression is reduced in a SigV mutant PubMed
Regulatory mechanism
FatR: repression, PubMed, in fatR regulon
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
SigW: sigma factor, PubMed, in sigW regulon
SigX: sigma factor, PubMed, in sigX regulon
Additional information
A ncRNA (RnaC) is encoded between 'yrhK' and 'yrhJ' PubMed
Open in new tab

fatR→yrhJ

2025-05-10 17:35:19

ghost

124

66cb5559018da57885af62dd768f226a6671d3f3

217BE52444D2B4A4024C5CD0426AE4112885843E

Genes
yrhH-fatR-yrhJ
Description
PubMed
Regulation
Expressed under stress conditions (SigW, SigX) PubMed
Additional information
A ncRNA (RnaC) is encoded between 'yrhK' and 'yrhJ' PubMed
Open in new tab

yrhH→yrhJ

2025-05-10 13:15:02

ghost

95

6a319165d87b6e310ceee6802fc5be1260c7635a

96207AF27502FF7704502BDB88571F1FEBAA2D56

Biological materials
Mutant
MGNA-A177 (yrhI::erm), available at the NBRP B. subtilis, Japan
BKE27170 (fatR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTAATCTGACAACCTCC,  downstream forward: _UP4_CAAAAATAGGAAAGGGAGAT
BKK27170 (fatR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTAATCTGACAACCTCC,  downstream forward: _UP4_CAAAAATAGGAAAGGGAGAT
References
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3DA3FFB295F5513A220CB163994EE0F356C810E6

Page visits: 6043

Time of last update: 2025-05-13 15:14:57

Author of last update: Melvin.boenninger