pth

pth
168

peptidyl-tRNA hydrolase, general stress protein

locus
BSU_00530
Molecular weight
20.73 kDa
pI
5.58
Protein length
188 aaSequenceBlast
Gene length
567 bpSequenceBlast
function
ribosome-associated quality control
product
peptidyl-tRNA hydrolase
essential
yes
ec
3.1.1.29
synonyms
spoVC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0193 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
59,504 → 60,070
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
H2O + N-acyl-L-α-aminoacyl-tRNA --> N-acyl-L-amino acid + H+ + tRNA (according to UniProt)
Protein family
PTH family (single member, according to UniProt)
Structure
[PDB|4QT4] (from ''Streptococcus pyogenes'', 48% identity) [Pubmed|25389518]
[AF|P37470]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|40624E9FC30D75D172EF098C7FAC77B2573CC129|ctc]-[gene|FE7859E98F26E532AE02CD71B42B845BADBCF06E|pth]-[gene|C595D32D98723E93AF26B5C864FD61AF4739E069|fin]
description
[pubmed|22383849]
regulation
induced under stress conditions ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]) [pubmed|15805528]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
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[gene|40624E9FC30D75D172EF098C7FAC77B2573CC129|ctc]→[gene|C595D32D98723E93AF26B5C864FD61AF4739E069|fin]

2024-10-04 09:34:37

Jstuelk

112

042d8e5a6f42561738123d446c8cdfdcb7b024b0

AF90CE02D929F6F737FC233892E7E08A4B249DEC

References
11544224,12100553,25389518,35638784

FE7859E98F26E532AE02CD71B42B845BADBCF06E

Page visits: 5065

Time of last update: 2024-12-21 15:14:16

Author of last update: Jstuelk