sigB

sigB
168

[wiki|RNA polymerase] [wiki|sigma factor] [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]

locus
BSU_04730
Molecular weight
29.99 kDa
pI
5.42
Protein length
262 aaSequenceBlast
Gene length
789 bpSequenceBlast
function
general stress response, biocontrol of fungal growth
product
[wiki|RNA polymerase] [wiki|sigma factor] [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]
essential
no
synonyms
sigB, rpoF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5812 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
522,862  523,650
The protein
Protein family
[wiki|Sigma-70 factor family] (according to UniProt)
Structure
[PDB|1L0O] ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]-[protein|search|SpoIIAB ]complex from Geobacillus stearothermophilus, 32% identity) [pubmed|11955433]
[AF|P06574]
Effectors of protein activity
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB] is activated during bacterial-fungal interaction (via [protein|9284E58A2D5394A31658E70879874A1338CF531B|rsbP]) [pubmed|30824454]
Expression and Regulation
Operons
genes
[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-[gene|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-[gene|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT]-[gene|0B8381D2C724DAA724E4AFC67000F12AD112D13D|rsbU]-[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|8002610]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|20454630], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8002610], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Open in new tab

[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]→[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]

2024-12-15 16:21:36

ghost

187

5f220975cc2493224a8aa0770ee2187c815a2127

3EFC8DC1AC54632D4F2AC30497749AB5CCA3A39F

genes
[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|2170324]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
Open in new tab

[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]→[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]

2024-12-06 12:20:01

ghost

115

c245857c04f8cca86e1f0627f3b25353c582e66e

E6CC0B507AA5819A4C5EBF800596629708A2B80D

Biological materials
Mutant
QB5344 (cat), available in [wiki|Jörg Stülke]'s lab
1A675 ( ''sigB''::''cat''), [Pubmed|3027048], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A675&Search=1A675 BGSC]
1A777 ( ''sigB''::''cat''), [Pubmed|1744042], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A777&Search=1A777 BGSC]
1A780 ( ''sigB''::''spec''), [Pubmed|8253681], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A780&Search=1A780 BGSC]
BKE04730 ([gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04730 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCTTATGAGCCGATCGACTT,  downstream forward: _UP4_GATCCCTCGATGGAGTTAAT
BKK04730 ([gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04730 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCTTATGAGCCGATCGACTT,  downstream forward: _UP4_GATCCCTCGATGGAGTTAAT
labs
[wiki|Bill Haldenwang], San Antonio, USA
[wiki|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
References
Reviews
19575568,18035607,11407115,9767581,20658979,27518094,28271471,33042030,33544236,37251512
Other publications
36815589,23407164,22511268,22210769,23524614,21979936,8655572,3123466,10369900,3112122,8468294,8458834,13129942,6784117,12867438,3100810,8253681,12486038,8764398,3027048,15342585,17575448,17586624,23934352,25652417,3016731,11902719,14651641,10503549,15205443,6405278,10383961,15805528,6790515,116131,19948797,22582280,24572018,24878601,27977677,28461450,11955433,28727759,29454936,30396900,30824454,31210376,32075967,32373088,33927010,36409125,38236030
Identification of the SigB regulon
11544224,11532142,11717291,10482513,10220166,22174379,33466511,36653740
Control of SigB activity by protein-protein interactions
11377871,12270815,15312768,8460143,8682769,8002610,11591687,7601843,17498739,15342582,32695420,36552239,37540712,39194552

580011DE5DC40EC9E7E0512791D328FAA010DCB8

Page visits: 21066

Time of last update: 2024-12-19 00:35:22

Author of last update: Jstuelk