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bceR
168
two-component response regulator ([wiki|OmpR family]), regulation of [gene|8E0DE8FE7E9C12495C4DCADA74D838FED088867D|bceA]-[gene|search|bceB ]in response to external (bacitracin, plectasin, mersacidin and actagardine) and internal ([protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|sdpC], [protein|DDB0022F50999AC52809D651C9CC5A5FDC71302C|skfA]) antimicrobial peptides
Molecular weight
26.72 kDa
function
resistance against toxic peptides
product
two-component response regulator ([wiki|OmpR family])
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,113,187 → 3,113,882
The protein
Protein family
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-116) (according to UniProt)
Structure
[PDB|1KGS] (DrrD from ''Thermotoga maritima '', 32% identity) [Pubmed|11839301]
[AF|O34951]
Modification
phosphorylated by [protein|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS] on an Asp residue
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]-[gene|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS]
description
[Pubmed|12399481]
[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]→[gene|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS]
2024-12-12 13:05:40
ghost
69
0d9c5f5aba9cd37b65e502c54a394ddb9aea0053
3ED24B86B015CF9A9605EB84290EFCB74C536FCF
Biological materials
Mutant
GP3218 Δ([gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]-[gene|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS]-[gene|8E0DE8FE7E9C12495C4DCADA74D838FED088867D|bceA]-[gene|E3613A6C8B5F0EC76510ACE3E478967E73E2B241|bceB])::''cat'', available in [wiki|Jörg Stülke]'s lab
MGNA-A133 (ytsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/133 NBRP B. subtilis, Japan]
BKE30400 (Δ[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAA
BKK30400 (Δ[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAA
References
Reviews
27344142,28152228,29404338,33450852,38460782,38869304 Original Publications
10094672,18394148,12890034,14651641,21283517,20606066,17905982,25118291,22964256,21078927,26199330,26364265,11839301,27997719
