ctaD

ctaD
168

cytochrome-c oxidase (caa3) (subunit I)

Locus
BSU_14900
Molecular weight
68.93 kDa
Isoelectric point
6.99
Protein length
622 aaSequenceBlast
Gene length
1869 bpSequenceBlast
Function
respiration
Product
cytochrome-c oxidase (subunit I)
Essential
no
E.C.
1.9.3.1
Synonyms
ctaD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0843 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,561,569  1,563,437
Phenotypes of a mutant
essential according to PubMed, non-essential according to PubMed
The protein
Catalyzed reaction/ biological activity
4 [Fe(II)cytochrome c] + 4 H+ + O2 --> 4 [Fe(III)cytochrome c] + 2 H2O (according to UniProt)
Protein family
heme-copper respiratory oxidase family (with QoxB, according to UniProt)
Cofactors
2 heme A molecules, Cu(B) PubMed
Structure
1FFT (PDB) (the protein from E. coli, 44% identity) PubMed
P24010 (AlphaFold)
Paralogous protein(s)
QoxB
Localization
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
ctaB-ctaC-ctaD-ctaE-ctaF-ctaG
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
ResD: activation, PubMed, in resD regulon
Abh: repression, synergistic repression with AbrB, in abh regulon
CcpA: repression, in ccpA regulon
AbrB: repression, synergistic repression with Abh, in abrB regulon
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ctaB→ctaG

2025-04-02 20:43:08

Jstuelk

89

57a66966d938d516e5885dbc6c6a07dd7fdfd454

61117927D388B0F9733EEB1889206DE9FFA99028

Additional information
translation is likely to require Efp due to the presence of several consecutive proline residues PubMed
Biological materials
Mutant
BKE14900 (ctaD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTGACCTCCCCCAAT,  downstream forward: _UP4_GATGATAAAGGGGTGAAGGC
BKK14900 (ctaD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTGACCTCCCCCAAT,  downstream forward: _UP4_GATGATAAAGGGGTGAAGGC
References
Reviews
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Original Publications
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20D1174554A03EECE233A1A045F6DF83AF799959

Page visits: 4245

Time of last update: 2025-04-07 17:42:41

Author of last update: Jstuelk