ctaD

ctaD
168

cytochrome-c oxidase (caa3) (subunit I)

locus
BSU_14900
Molecular weight
68.93 kDa
pI
6.99
Protein length
Gene length
function
respiration
product
cytochrome-c oxidase (subunit I)
essential
no
ec
1.9.3.1
synonyms
ctaD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0843 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,561,569  1,563,437
Phenotypes of a mutant
essential according to [Pubmed|17114254], non-essential according to [Pubmed|10551842]
The protein
Catalyzed reaction/ biological activity
4 [Fe(II)cytochrome c] + 4 H+ + O2 --> 4 [Fe(III)cytochrome c] + 2 H2O (according to UniProt)
Protein family
heme-copper respiratory oxidase family (with [protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB], according to UniProt)
[wiki|Cofactors]
2 heme A molecules, Cu(B) [Pubmed|10837475]
Structure
[PDB|1FFT] (the protein from E. coli, 44% identity) [pubmed|11017202]
[AF|P24010]
Paralogous protein(s)
[protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]
description
[Pubmed|9829923]
regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|9829923]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|9829923], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB], in [regulon|protein:5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Open in new tab

[gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]→[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]

2024-09-28 22:05:07

Jstuelk

71

57a66966d938d516e5885dbc6c6a07dd7fdfd454

61117927D388B0F9733EEB1889206DE9FFA99028

additional information
[protein|search|translation] is likely to require [protein|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
Biological materials
Mutant
BKE14900 ([gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14900 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGTGACCTCCCCCAAT,  downstream forward: _UP4_GATGATAAAGGGGTGAAGGC
BKK14900 ([gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14900 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGTGACCTCCCCCAAT,  downstream forward: _UP4_GATGATAAAGGGGTGAAGGC
References
Reviews
33705278
Original Publications
1685007,10551842,9829923,17114254,20817675,10837475,27503613,11017202,36422766

20D1174554A03EECE233A1A045F6DF83AF799959

Page visits: 3804

Time of last update: 2024-10-06 06:25:49

Author of last update: Jstuelk