efp

efp
168

elongation factor P, important for the [category|SW.3.3.1|Translation] of proteins containing three or more consecutive proline residues

locus
BSU_24450
Molecular weight
20.31 kDa
pI
4.84
Protein length
Gene length
function
[category|SW.3.3.1|Translation]
product
elongation factor P
essential
no
synonyms
efp, yqhU, yqgF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0231 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,538,115  2,538,672
Phenotypes of a mutant
defective in [category|SW.4.1.4|Swarming] motility [pubmed|35638827,15066026,27002156]
inactivation of ''[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]'' reduces sporulation efficiency to 1% that of wild type cells [Pubmed|26735940]
an [gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp] [gene|F69F15198ACF8A8347C450EEC09F000EECEDEC41|yfmR] double mutant is not viable [pubmed|37577462]
The protein
Catalyzed reaction/ biological activity
see a list of [category|SW.6.11|Efp-dependent proteins]
Protein family
elongation factor P family (single member, according to UniProt)
Structure
[PDB|6RK3] (from Staphylococcus aureus, 71% identity) [pubmed|32152681]
[AF|P49778]
Modification
carries a 5-aminopentanol moiety at Lys-32, this modification is essential for activity [Pubmed|27002156]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
Expression and Regulation
Operons
genes
[gene|449EEBF33F52B461F244331ACD140E68CF64EE7C|figP]-[gene|D7503C73C0BC2E411C651E409E91C2E22E8842E5|yqhS]-[gene|33886A1EAC13B684E92BF94201C46617AD2844B3|papA]-[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]
description
[pubmed|22383849]
Open in new tab

[gene|449EEBF33F52B461F244331ACD140E68CF64EE7C|figP]→[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]

2024-11-26 17:49:33

Jstuelk

93

5a3af415b3d477ed26b5a5ba683e8b71aa900cda

4C13A03AFAA21B82D13D48369D7EA262D08E39DE

genes
[gene|D7503C73C0BC2E411C651E409E91C2E22E8842E5|yqhS]-[gene|33886A1EAC13B684E92BF94201C46617AD2844B3|papA]-[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]
description
[pubmed|22383849]
Open in new tab

[gene|D7503C73C0BC2E411C651E409E91C2E22E8842E5|yqhS]→[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]

2024-11-26 06:12:28

Jstuelk

96

04645919ad54957aa4b00016a6391e23f3845b46

AAFB82DFDDF37319D77CE472A297D3AA713E6311

Biological materials
Mutant
MGNA-C464 (efp::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2462 NBRP B. subtilis, Japan]
BKE24450 (''[gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]''::''erm'', available in the BGSC and in [wiki|Jörg Stülke]'s lab) [pubmed|28189581]
BKE24450 ([gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24450 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTTAATGTCCTCCTAT,  downstream forward: _UP4_TAGAAAGAAAAAAAGAAGTC
BKK24450 ([gene|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24450 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTTAATGTCCTCCTAT,  downstream forward: _UP4_TAGAAAGAAAAAAAGAAGTC
References
Reviews
26416626,28886684,32011712
Original Publications
36815589,15066026,17981983,23239624,23239623,25310979,25144653,27002156,26735940,27216360,26384033,28787546,28765223,29615499,30297417,32152681,35638827,36651772,37577462

3054CD45713BBD69C2A528DE24AF6AF37175FD9D

Page visits: 4617

Time of last update: 2024-12-05 13:17:49

Author of last update: Jstuelk