Biosynthesis of cofactors

Parent categories	2. Metabolism 2.6. Additional metabolic pathways
Neighbouring categories	2.6.1. Biosynthesis of cell wall components 2.6.2. Biosynthesis of cofactors 2.6.3. Phosphate metabolism 2.6.4. Sulfur metabolism 2.6.5. Iron metabolism 2.6.6. Miscellaneous metabolic pathways
Related categories	BirA regulon FMN-box NadR regulon Thi-box
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

Biosynthesis/ acquisition of biotin

• bioA
• bioB
• bioD
• bioF
• bioI
• bioW
• birA
• yhfU

Biosynthesis/ acquisition of riboflavin/ fad

• ribA
• ribC
• ribD
• ribE
• ribH
• ribR
• ribT
• ribU
• ycsE

Biosynthesis/ acquisition of thiamine

• dxs
• tenA
• tenI
• thiC
• thiD
• thiE
• thiF
• thiG
• thiL
• thiM
• thiO
• thiS
• thiT
• thiU
• thiV
• thiW
• thiX
• ylmB
• yloS

Biosynthesis of coenzyme a

• coaA
• coaX
• panB
• panC
• panD
• ylbQ
• yloI
• ytaG

Biosynthesis of folate

• dfrA
• folB
• folC
• folE
• folE2
• folK
• pabA
• pabB
• pabC
• sul

Biosynthesis of heme/ siroheme

• ctaA
• ctaB
• ctaO
• gsaB
• hemA
• hemB
• hemC
• hemD
• hemE
• hemH
• hemL
• hemN
• hemQ
• hemX
• hemY
• hemZ
• ylnD
• ylnE
• ylnF

Biosynthesis of lipoic acid (For complete biosynthetic pathway see PubMed)

• lipA
• lipM
• lplJ
• lipL
• gcvH

Biosynthesis of menaquinone

• hepS
• hepT
• menA
• menB
• menC
• menD
• menE
• menF
• menH

Biosynthesis of menaquinone/ based on similarity

• ytxM

Biosynthesis of molybdopterin

• moaA
• moaB
• moaD
• moaE
• mobA
• mobB
• moeA
• moeB
• ydiG

Biosynthesis of nad(p)

• nadA
• nadB
• nadC
• nadD
• nadE
• nadF
• nadR
• niaP
• nifS
• ytdI

Biosynthesis of pyridoxal phosphate

• pdxK
• pdxS
• pdxT

Metabolism of cofactors in SubtiPathways

• CoA synthesis

• Folate biosynthesis

• Menaquinone

• Riboflavin and FAD synthesis

• Thiamin synthesis

• Biotin synthesis

Important original publications

<pubmed> 24972371 28196402</pubmed>

Important reviews

<pubmed> 11153271 22616866 19348578 18314013 14675553 10382260 24442413 21646432,21437340 26758294 27074917 27890703</pubmed>