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A riboswitch that controls the expression of the tenA-tenI-thiO-thiS-thiG-thiF-thiD and thiU-thiV-thiW-thiX operons as well as of the thiC, thiT, and ylmB genes in response to thiamine. Thiamine pyrophosphate binds the Thi-box resulting in reduced expression.

Important Reviews

Elnaz Mehdizadeh Aghdam, Malte Sinn, Vahideh Tarhriz, Abolfazl Barzegar, Jörg S Hartig, Mohammad Saeid Hejazi
TPP riboswitch characterization in Alishewanella tabrizica and Alishewanella aestuarii and comparison with other TPP riboswitches.
Microbiol Res: 2017, 195;71-80
[PubMed:28024528] [] [DOI] (I p)

Elena Cressina, Liuhong Chen, Michael Moulin, Finian J Leeper, Chris Abell, Alison G Smith
Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches.
Biochem Soc Trans: 2011, 39(2);652-7
[PubMed:21428956] [] [DOI] (I p)

Stephanie Furniss, Neena Grover
Thermodynamic examination of the pyrophosphate sensor helix in the thiamine pyrophosphate riboswitch.
RNA: 2011, 17(4);710-7
[PubMed:21367973] [] [DOI] (I p)

Juan Miranda-Ríos
The THI-box riboswitch, or how RNA binds thiamin pyrophosphate.
Structure: 2007, 15(3);259-65
[PubMed:17355861] [] [DOI] (P p)

Narasimhan Sudarsan, Smadar Cohen-Chalamish, Shingo Nakamura, Gail Mitchell Emilsson, Ronald R Breaker
Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine.
Chem Biol: 2005, 12(12);1325-35
[PubMed:16356850] [] [DOI] (P p)

Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
J Biol Chem: 2002, 277(50);48949-59
[PubMed:12376536] [] [DOI] (P p)

J Miranda-Ríos, M Navarro, M Soberón
A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria.
Proc Natl Acad Sci U S A: 2001, 98(17);9736-41
[PubMed:11470904] [] [DOI] (P p)

See also:

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