Proteolysis

Parent categories	3. Information processing 3.3. Protein synthesis, modification and degradation
Neighbouring categories	3.3.1. Translation 3.3.2. Chaperones/ protein folding 3.3.3. Protein modification 3.3.4. Protein secretion 3.3.5. Proteolysis
Related categories	none
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

Protein quality control

• htrA
• htrB
• htrC
• wprA

Extracellular feeding proteases

• AprE and NprE account for 95% of extracellular proteolytic activity

• aprE
• bpr
• epr
• mpr
• nprB
• nprE
• vpr

• A mutant strain with deletions of all feeding proteases and the three major protein quality control proteases (htrA, htrB, wprA) (BRB14) is available in Colin Harwood's lab PubMed

Proteolysis during sporulation/ germination

• gpr
• tepA
• ylzJ
• spoIIGA
• spoIVFB

Additional proteins involved in proteolysis

• clpC
• clpE
• clpP
• clpQ
• clpX
• clpY
• ctpA
• ctpB
• ctsR
• ftsH
• htpX
• immA
• ipi
• ispA
• lonA
• lonB
• mecA
• mlpA
• prsW
• rasP

• yabG
• yirB
• yjbH
• ypbH
• ypwA
• yqgP
• yraA

Important reviews

Susanne Pohl, Gaurav Bhavsar, Joanne Hulme, Alexandra E Bloor, Goksel Misirli, Matthew W Leckenby, David S Radford, Wendy Smith, Anil Wipat, E Diane Williamson, Colin R Harwood, Rocky M Cranenburgh
Proteomic analysis of Bacillus subtilis strains engineered for improved production of heterologous proteins.
Proteomics: 2013, 13(22);3298-308
[PubMed:24115457] [WorldCat.org] [DOI] (I p)

Lee Kroos, Yoshinori Akiyama
Biochemical and structural insights into intramembrane metalloprotease mechanisms.
Biochim Biophys Acta: 2013, 1828(12);2873-85
[PubMed:24099006] [WorldCat.org] [DOI] (P p)

Noël Molière, Kürşad Turgay
General and regulatory proteolysis in Bacillus subtilis.
Subcell Biochem: 2013, 66;73-103
[PubMed:23479438] [WorldCat.org] [DOI] (P p)

Aurelia Battesti, Susan Gottesman
Roles of adaptor proteins in regulation of bacterial proteolysis.
Curr Opin Microbiol: 2013, 16(2);140-7
[PubMed:23375660] [WorldCat.org] [DOI] (I p)

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)

Sinisa Urban
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.
Nat Rev Microbiol: 2009, 7(6);411-23
[PubMed:19421188] [WorldCat.org] [DOI] (I p)