GalE

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  • Description: UDP glucose 4-epimerase

Gene name galE
Synonyms
Essential no
Product UDP glucose 4-epimerase
Function galactose utilization
Gene expression levels in SubtiExpress: galE
Metabolic function and regulation of this protein in SubtiPathways:
galE
MW, pI 36 kDa, 4.776
Gene length, protein length 1017 bp, 339 aa
Immediate neighbours yxkC, yxkA
Sequences Protein DNA DNA_with_flanks
Genetic context
GalE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GalE expression.png



















Categories containing this gene/protein

utilization of specific carbon sources, biofilm formation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU38860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-glucose = UDP-galactose (according to Swiss-Prot)
  • Protein family: sugar epimerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1LRL (from Escherichia coli Y299C mutant, 57% identity, 71% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • strongly repressed in response to glucose starvation in M9 medium PubMed
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 2076 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 3361 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 2975 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 1717 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 3186 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References