Difference between revisions of "Biosynthesis of cofactors"

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(Created page with " {{CategoryTree |Parents= * 2. Metabolism ** 2.6. Additional metabolic pathways |Neighbours= * 2.6.1. Biosynthesis of cell wall components * 2.6.2. [[Biosynthesis of ...")
 
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{{CategoryTree
 
{{CategoryTree
 
|Parents=
 
|Parents=
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* 2.6.6. [[Miscellaneous metabolic pathways]]
 
* 2.6.6. [[Miscellaneous metabolic pathways]]
 
|Related=
 
|Related=
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none
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* [[BirA regulon]]
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* [[FMN-box]]
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* [[NadR regulon]]
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* [[Thi-box]]
 
|}}
 
|}}
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== Genes in this functional category ==
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=== Biosynthesis/ acquisition of biotin ===
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* [[bioA]]
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* [[bioB]]
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* [[bioD]]
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* [[bioF]]
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* [[bioI]]
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* [[bioW]]
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* [[birA]]
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* [[yhfU]]
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=== Biosynthesis/ acquisition of riboflavin/ fad ===
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* ''[[ribA]]''
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* ''[[ribC]]''
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* ''[[ribD]]''
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* ''[[ribE]]''
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* ''[[ribH]]''
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* ''[[ribR]]''
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* ''[[ribT]]''
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* ''[[ribU]]''
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* ''[[ycsE]]''
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=== Biosynthesis/ acquisition of thiamine ===
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* [[dxs]]
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* [[tenA]]
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* [[tenI]]
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* [[thiC]]
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* [[thiD]]
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* [[thiE]]
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* [[thiF]]
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* [[thiG]]
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* [[thiL]]
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* [[thiM]]
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* [[thiO]]
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* [[thiS]]
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* [[thiT]]
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* [[thiU]]
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* [[thiV]]
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* [[thiW]]
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* [[thiX]]
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* [[ylmB]]
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* [[yloS]]
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=== Biosynthesis of coenzyme a ===
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* [[coaA]]
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* [[coaX]]
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* [[panB]]
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* [[panC]]
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* [[panD]]
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* [[ylbQ]]
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* [[yloI]]
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* [[ytaG]]
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=== Biosynthesis of folate ===
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* [[dfrA]]
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* [[folB]]
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* [[folC]]
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* [[folE]]
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* [[folE2]]
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* [[folK]]
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* [[pabA]]
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* [[pabB]]
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* [[pabC]]
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* [[sul]]
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=== Biosynthesis of heme/ siroheme ===
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* [[ctaA]]
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* [[ctaB]]
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* [[ctaO]]
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* [[gsaB]]
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* [[hemA]]
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* [[hemB]]
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* [[hemC]]
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* [[hemD]]
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* [[hemE]]
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* [[hemH]]
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* [[hemL]]
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* [[hemN]]
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* [[hemQ]]
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* [[hemX]]
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* [[hemY]]
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* [[hemZ]]
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* [[ylnD]]
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* [[ylnE]]
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* [[ylnF]]
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=== Biosynthesis of lipoic acid (For complete biosynthetic pathway see {{PubMed|21338421}}) ===
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* [[lipA]]
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* [[lipM]]
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* [[lplJ]]
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* [[lipL]]
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* [[gcvH]]
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=== Biosynthesis of menaquinone ===
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* [[hepS]]
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* [[hepT]]
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* [[menA]]
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* [[menB]]
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* [[menC]]
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* [[menD]]
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* [[menE]]
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* [[menF]]
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* [[menH]]
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=== Biosynthesis of menaquinone/ based on similarity ===
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* [[ytxM]]
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=== Biosynthesis of molybdopterin ===
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* [[moaA]]
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* [[moaB]]
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* [[moaD]]
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* [[moaE]]
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* [[mobA]]
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* [[mobB]]
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* [[moeA]]
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* [[moeB]]
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* [[ydiG]]
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=== Biosynthesis of nad(p) ===
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* ''[[nadA]]''
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* ''[[nadB]]''
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* ''[[nadC]]''
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* ''[[nadD]]''
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* ''[[nadE]]''
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* ''[[nadF]]''
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* ''[[nadR]]''
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* ''[[niaP]]''
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* ''[[nifS]]''
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* ''[[ytdI]]''
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=== Biosynthesis of pyridoxal phosphate ===
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* [[pdxK]]
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* [[pdxS]]
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* [[pdxT]]
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== Metabolism of cofactors in [http://subtiwiki.uni-goettingen.de/subtipathways.html ''Subti''Pathways]==
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* [http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html CoA synthesis]
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* [http://subtiwiki.uni-goettingen.de/pathways/folate_biosynthesis.html Folate biosynthesis]
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* [http://subtiwiki.uni-goettingen.de/pathways/menaquinone.html Menaquinone]
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* [http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin and FAD synthesis]
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* [http://subtiwiki.uni-goettingen.de/pathways/thiamin.html Thiamin synthesis]
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* [http://subtiwiki.uni-goettingen.de/pathways/biotin/index.html Biotin synthesis]
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==Important original publications==
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<pubmed> 24972371 28196402</pubmed>
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==Important reviews==
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<pubmed> 11153271 22616866 19348578 18314013 14675553 10382260 24442413 21646432,21437340 26758294 27074917    27890703</pubmed>
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=Back to [[categories]]=

Latest revision as of 16:58, 15 February 2017

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

Biosynthesis/ acquisition of biotin

Biosynthesis/ acquisition of riboflavin/ fad

Biosynthesis/ acquisition of thiamine

Biosynthesis of coenzyme a

Biosynthesis of folate

Biosynthesis of heme/ siroheme

Biosynthesis of lipoic acid (For complete biosynthetic pathway see PubMed)

Biosynthesis of menaquinone

Biosynthesis of menaquinone/ based on similarity

Biosynthesis of molybdopterin

Biosynthesis of nad(p)

Biosynthesis of pyridoxal phosphate

Metabolism of cofactors in SubtiPathways

Important original publications

Miglena Manandhar, John E Cronan
Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis.
Mol Microbiol: 2017, 104(4);595-607
[PubMed:28196402] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Ariane Alzinger, Rafael Sande, Werner Bretzel, Frederik M Meyer, Bastien Chevreux, Markus Wyss, Hans-Peter Hohmann, Zoltán Prágai
Overexpression of a non-native deoxyxylulose-dependent vitamin B6 pathway in Bacillus subtilis for the production of pyridoxine.
Metab Eng: 2014, 25;38-49
[PubMed:24972371] [WorldCat.org] [DOI] (I p)


Important reviews

Jonathan Rosenberg, Till Ischebeck, Fabian M Commichau
Vitamin B6 metabolism in microbes and approaches for fermentative production.
Biotechnol Adv: 2017, 35(1);31-40
[PubMed:27890703] [WorldCat.org] [DOI] (I p)

John E Cronan
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
Microbiol Mol Biol Rev: 2016, 80(2);429-50
[PubMed:27074917] [WorldCat.org] [DOI] (I e)

Susanne Katharina Schwechheimer, Enoch Y Park, José Luis Revuelta, Judith Becker, Christoph Wittmann
Biotechnology of riboflavin.
Appl Microbiol Biotechnol: 2016, 100(5);2107-19
[PubMed:26758294] [WorldCat.org] [DOI] (I p)

Markus Birkenmeier, Susanne Neumann, Thorsten Röder
Kinetic modeling of riboflavin biosynthesis in Bacillus subtilis under production conditions.
Biotechnol Lett: 2014, 36(5);919-28
[PubMed:24442413] [WorldCat.org] [DOI] (I p)

Tadhg P Begley, Steven E Ealick, Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochem Soc Trans: 2012, 40(3);555-60
[PubMed:22616866] [WorldCat.org] [DOI] (I p)

Charles A Abbas, Andriy A Sibirny
Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers.
Microbiol Mol Biol Rev: 2011, 75(2);321-60
[PubMed:21646432] [WorldCat.org] [DOI] (I p)

Steven Lin, John E Cronan
Closing in on complete pathways of biotin biosynthesis.
Mol Biosyst: 2011, 7(6);1811-21
[PubMed:21437340] [WorldCat.org] [DOI] (I p)

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

Tadhg P Begley, Abhishek Chatterjee, Jeremiah W Hanes, Amrita Hazra, Steven E Ealick
Cofactor biosynthesis--still yielding fascinating new biological chemistry.
Curr Opin Chem Biol: 2008, 12(2);118-25
[PubMed:18314013] [WorldCat.org] [DOI] (P p)

Ethan Settembre, Tadhg P Begley, Steven E Ealick
Structural biology of enzymes of the thiamin biosynthesis pathway.
Curr Opin Struct Biol: 2003, 13(6);739-47
[PubMed:14675553] [WorldCat.org] [DOI] (P p)

A Marquet, B T Bui, D Florentin
Biosynthesis of biotin and lipoic acid.
Vitam Horm: 2001, 61;51-101
[PubMed:11153271] [WorldCat.org] [DOI] (P p)

T P Begley, D M Downs, S E Ealick, F W McLafferty, A P Van Loon, S Taylor, N Campobasso, H J Chiu, C Kinsland, J J Reddick, J Xi
Thiamin biosynthesis in prokaryotes.
Arch Microbiol: 1999, 171(5);293-300
[PubMed:10382260] [WorldCat.org] [DOI] (P p)


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