Difference between revisions of "Response regulator aspartate phosphatases"
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Revision as of 08:27, 8 February 2010
These proteins contain the so-called tetratricopeptide repeats (TPRs) protein-protein interaction module. They control the phosphorelay for sporulation initiation by dephosphorylating Spo0F-P or they inhibit transcription factors by protein-protein interaction (without affecting phosphorylation). The activity of these proteins can be controlled by small peptides that are expressed as precursors, exported, and re-imported into the cell.
The RAP proteins of B. subtilis, their cognate peptides and target proteins
- RapA, PhrA: RapA dephosphorylates Spo0F-P
- RapB: dephosphorylates Spo0F-P
- RapC, PhrC: RapC inhibits the DNA-binding activity of ComA-P
- RapD: RapD inhibits the DNA-binding activity of ComA-P
- RapE, PhrE: RapE dephosphorylates Spo0F-P
- RapF, PhrF: RapF inhibits the DNA-binding activity of ComA-P
- RapG, PhrG: RapG inhibits the DNA-binding activity of DegU-P
- RapH: bifuntional protein: dephosphorylates Spo0F-P and inhibits the DNA-binding activity of ComA-P
- RapI, PhrI: RapI inhibits the DNA-binding activity of ImmR
- RapJ: unknown function
- RapK, PhrK: RapK inhibits the DNA-binding activity of ComA-P
Related lists
Reviews
Ruth E Silversmith
Auxiliary phosphatases in two-component signal transduction.
Curr Opin Microbiol: 2010, 13(2);177-83
[PubMed:20133180]
[WorldCat.org]
[DOI]
(I p)
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
M Perego, J A Brannigan
Pentapeptide regulation of aspartyl-phosphate phosphatases.
Peptides: 2001, 22(10);1541-7
[PubMed:11587783]
[WorldCat.org]
[DOI]
(P p)
J Reizer, A Reizer, M Perego, M H Saier
Characterization of a family of bacterial response regulator aspartyl-phosphate (RAP) phosphatases.
Microb Comp Genomics: 1997, 2(2);103-11
[PubMed:9689219]
[WorldCat.org]
[DOI]
(P p)
M Perego, P Glaser, J A Hoch
Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis.
Mol Microbiol: 1996, 19(6);1151-7
[PubMed:8730857]
[WorldCat.org]
[DOI]
(P p)
