mta

mta
168

transcriptional activator (MerR family) of multidrug-efflux transporter genes, activates ymfD expression

Locus
BSU_36600
Molecular weight
29.78 kDa
Isoelectric point
4.95
Protein length
257 aaSequenceBlast
Gene length
774 bpSequenceBlast
Function
regulation of multidrug-efflux transporter genes
Product
transcriptional activator (MerR family)
Essential
no
Synonyms
mta, ywnD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0789 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,764,133  3,764,906
The protein
Protein family
MerR family
Domains
HTH merR-type domain (aa 2-71) (according to UniProt)
Structure
1JBG (PDB) (N-terminal domain),  1R8D (PDB) (complex of N-terminal domain with DNA)
P71039 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
mta
Description
PubMed
Regulation
positive autoregulation PubMed
Regulatory mechanism
Mta: activation, PubMed, in mta regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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mta

2025-03-16 07:26:29

ghost

54

1eeb2776a74651aa7e3d8ac268407b9b7fe662f6

B33C77A595A4257EE0A1C1F0E45C755409D7804B

Biological materials
Mutant
MGNA-A197 (ywnD::erm), available at the NBRP B. subtilis, Japan
BKE36600 (mta::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACATAACACCTCCTCTT,  downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC
BKK36600 (mta::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACATAACACCTCCTCTT,  downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
Richard Brennan, Houston, Texas, USA Homepage
References
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A7326377132C670B60695EFE0A652B1E4F623698

Page visits: 4294

Time of last update: 2025-04-01 21:00:58

Author of last update: Melvin.boenninger