mta
168
transcriptional activator ([wiki|MerR family]) of multidrug-efflux transporter genes, activates [gene|11997FE6BA6947E7C7E3DBE20B49C9FB758262B2|ymfD] expression
locus
BSU_36600
Molecular weight
29.78 kDa
pI
4.95
function
regulation of multidrug-efflux transporter genes
product
transcriptional activator ([wiki|MerR family])
essential
no
synonyms
mta, ywnD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0789 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,764,133 3,764,906
The protein
Protein family
[wiki|MerR family]
[wiki|Domains]
[wiki|HTH merR-type domain] (aa 2-71) (according to UniProt)
Structure
[PDB|1JBG] (N-terminal domain), [PDB|1R8D] (complex of N-terminal domain with DNA)
[AF|P71039]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A7326377132C670B60695EFE0A652B1E4F623698|mta]
description
[Pubmed|9353933]
regulation
positive autoregulation [Pubmed|10200972]
regulatory mechanism
[protein|A7326377132C670B60695EFE0A652B1E4F623698|mta]: activation, [Pubmed|10200972], in [regulon|protein:A7326377132C670B60695EFE0A652B1E4F623698|mta regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10200972], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A197 (ywnD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/197 NBRP B. subtilis, Japan]
BKE36600 ([gene|A7326377132C670B60695EFE0A652B1E4F623698|mta]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACATAACACCTCCTCTT, downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC
BKK36600 ([gene|A7326377132C670B60695EFE0A652B1E4F623698|mta]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACATAACACCTCCTCTT, downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC
labs
[wiki|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
[wiki|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]
References
Page visits: 4023
Time of last update: 2024-11-09 02:19:30
Author of last update: Melvin.boenninger