map
168
methionine aminopeptidase
Locus
BSU_01380
Molecular weight
27.26 kDa
Isoelectric point
6.39
Function
removal of N-terminal methionine from nascent proteins
Product
methionine aminopeptidase
Essential
no
E.C.
3.4.11.18
Synonyms
map, mapA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0024 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
146,527 147,273
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides (according to UniProt)
Protein family
peptidase M24A family (with YflG, according to UniProt)
Structure
1O0X (PDB) (from Thermotoga maritima, 50% identity) PubMed
2MAT (PDB) (from Escherichia coli, 46% identity, 65% similarity) PubMed
Paralogous protein(s)
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Description
NULL
Regulation
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed (two promoters, about 140bp and 200bp upstream of the start codon), in sigA regulon
Additional information
strongly expressed
Genes
Description
Regulation
strongly repressed in response to glucose starvation in M9 medium PubMed
likely autorepression of operon expression upon binding of excess of one ribosomal protein to the untranslated region of the mRNA PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed (two promoters, about 140bp and 200bp upstream of the start codon), in sigA regulon
Additional information
term-seq has identified a potential novel regulatory RNA element (protein-dependent leader) including an intrinsic transcription terminator upstream of rpsJ PubMed
Biological materials
Mutant
References
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Time of last update: 2025-03-17 21:08:42
Author of last update: Jstuelk