spsE

spsE
168

legionaminic acid synthesis

Locus
BSU_37870
Molecular weight
40.73 kDa
Isoelectric point
5.23
Protein length
373 aaSequenceBlast
Gene length
1122 bpSequenceBlast
Function
legionaminic acid synthesis
Product
legionaminic acid synthase
Essential
no
Synonyms
spsE, ipa-67d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2089 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,887,741 → 3,888,862
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth PubMed
less hydrophobic spore surface PubMed
The protein
Catalyzed reaction/ biological activity
required for spore crust assembly, legionaminic acid synthesis PubMed
Domains
AFP-like domain (aa 305-367) (according to UniProt)
Structure
1VLI (PDB)
P39625 (AlphaFold)
Expression and Regulation
Operons
Genes
spsA-spsB-spsC-spsD-spsE-spsF-spsG-spsI-spsJ-spsK-spsL
Description
PubMed
Regulation
expressed during sporulation in the mother cell (SigE, SigK, GerE) PubMed
Regulatory mechanism
GerE: activation, PubMed, in gerE regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
SigK: sigma factor, PubMed, in sigK regulon
Additional information
the mRNA is very stable (half-life > 15 min) PubMed
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spsA→spsL

2025-04-07 10:32:08

ghost

135

8fd40e70daa9bc3b7d469fa252e122a98e4555de

9FCD794B68194823BCA66D7E89CC93E5AF9CC0AA

Biological materials
Mutant
BKE37870 (ΔspsE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCGCGATCTGAAACGCTG,  downstream forward: _UP4_ATTTTACTGAAGGACAGCCC
BKK37870 (ΔspsE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCGCGATCTGAAACGCTG,  downstream forward: _UP4_ATTTTACTGAAGGACAGCCC
References
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Time of last update: 2025-04-10 21:23:34

Author of last update: Jstuelk