yhcY
168

two-component sensor kinase

Locus

BSU_09320

Molecular weight

41.83 kDa

Isoelectric point

6.64

Protein length

379 aaSequenceBlast

Gene length

1140 bpSequenceBlast

Function

unknown

Product

two-component sensor kinase

Essential

Synonyms

yhcY

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

Information processing, Protein synthesis, modification and degradation, Protein modification, Protein kinases

Information processing, Regulation of gene expression, Transcription factors and their control, Control of two-component response regulators, Two-component sensor kinase

Groups of genes, Phosphoproteins, Phosphorylation on a His residue

List of homologs in different organisms, belongs to COG4585 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, LiaR regulon

Gene

Coordinates

1,008,668 1,009,807

The protein

Catalyzed reaction/ biological activity

autophosphorylation, phosphorylation of YhcZ in a Asp residue

ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)

Domains

Histidine kinase domain (aa 185-373) (according to UniProt)

Structure

O07527 (AlphaFold)

Modification

autophosphorylation on a His residue

Localization

cytoplasm (Homogeneous) PubMed

Expression and Regulation

Operons

Genes

yhcY-yhcZ-yhdA

Description

PubMed

Regulatory mechanism

LiaR: activation, PubMed, in liaR regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

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Biological materials

Mutant

MGNA-A729 (yhcY::erm), available at the NBRP B. subtilis, Japan

BKE09320 (yhcY::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGTTTCTCACTCCGGCAT, downstream forward: _UP4_AAAAGCCGAAAAGGAGGGGC

BKK09320 (yhcY::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGTTTCTCACTCCGGCAT, downstream forward: _UP4_AAAAGCCGAAAAGGAGGGGC

References

Jia LD, Gao TT, Peng Q, Lv J, Zhang J, Chen M, Song FP [The functions of yhcZ gene during Bacillus thuringiensis growth]. Yi chuan = Hereditas. 2018 May 20; 40(5):415-424. doi:10.16288/j.yczz.18-061. PMID:29785949

Wolf D, Kalamorz F, Wecke T, Juszczak A, Mäder U, Homuth G, Jordan S, Kirstein J, Hoppert M, Voigt B, Hecker M, Mascher T In-depth profiling of the LiaR response of Bacillus subtilis. Journal of bacteriology. 2010 Sep; 192(18):4680-93. doi:10.1128/JB.00543-10. PMID:20639339

Jordan S, Junker A, Helmann JD, Mascher T Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system. Journal of bacteriology. 2006 Jul; 188(14):5153-66. . PMID:16816187

Meile JC, Wu LJ, Ehrlich SD, Errington J, Noirot P Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory. Proteomics. 2006 Apr; 6(7):2135-46. . PMID:16479537

Fabret C, Feher VA, Hoch JA Two-component signal transduction in Bacillus subtilis: how one organism sees its world. Journal of bacteriology. 1999 Apr; 181(7):1975-83. . PMID:10094672

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Time of last update: 2025-04-03 10:36:12

Author of last update: Melvin.boenninger

yhcY 168

yhcY
168