yhdA
168
NADPH-dependent FMN oxidoreductase
locus
BSU_09340
Molecular weight
18.76 kDa
pI
6.51
function
protection against oxidative stress
product
NADPH-dependent FMN oxidoreductase
essential
no
synonyms
yhdA, azr
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0431 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,010,445 1,010,969
The protein
Protein family
azoreductase type 2 family (single member, according to UniProt)
[wiki|Cofactors]
FMN [Pubmed|16752898]
NADPH [pubmed|32801174]
Structure
[PDB|3GFQ] (99% identity),
[PDB|1NNI]
[AF|O07529]
Paralogous protein(s)
[protein|CAFAE305B1771DD89E81F75A6713161393BE99A0|pgcM], (31%)
Expression and Regulation
Operons
genes
[gene|8D570AEE5D78A9A3CDBB1F457630BAF5DB59BCFD|yhcY]-[gene|DD799ED3EB79457C27ED30C7B4DBBC2C8F962191|yhcZ]-[gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]
description
[Pubmed|16816187]
regulatory mechanism
[protein|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|liaR]: activation, [Pubmed|16816187], in [regulon|protein:49E70A20CC05DBE485953C0AE34E634EFB33C3B2|liaR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16816187], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A689 (yhdA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/689 NBRP B. subtilis, Japan]
BKE09340 ([gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCATTTATGACTAACA, downstream forward: _UP4_GGCGTCTAAACGCCGGGATT
BKK09340 ([gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCATTTATGACTAACA, downstream forward: _UP4_GGCGTCTAAACGCCGGGATT
References
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Time of last update: 2025-04-02 06:51:10
Author of last update: Robert.warneke