Penicillin-binding proteins

Carboxypeptidases

• DacA PBP 5
• DacB PBP 5*
• DacC PBP4A
• DacF PBP I

Transpeptidases

• PbpA PBP2A
• PbpB PBP2B
• PbpC PBP3
• PbpH PBP H
• PbpI PBP4B
• SpoVD spore cortex-specific PBP

Endopeptidases

• PbpE PBP 4* (spore coat)
• PbpX PBP X

Bifunctional glucosyltransferases/ transpeptidases

• PbpD: PBP 4
• PbpF
• PbpG
• PonA: PBP 1

Related pages

• Cell wall synthesis
• Cell shape
• elongasome
• Cell wall synthesis in SubtiPathways

Important original publications

Yoshikazu Kawai, Katarzyna Mickiewicz, Jeff Errington
Lysozyme Counteracts β-Lactam Antibiotics by Promoting the Emergence of L-Form Bacteria.
Cell: 2018, 172(5);1038-1049.e10
[PubMed:29456081] [WorldCat.org] [DOI] (I p)

Jonathan M Fura, Daniel Kearns, Marcos M Pires
D-Amino Acid Probes for Penicillin Binding Protein-based Bacterial Surface Labeling.
J Biol Chem: 2015, 290(51);30540-50
[PubMed:26499795] [WorldCat.org] [DOI] (I p)

Ozden Kocaoglu, Rebecca A Calvo, Lok-To Sham, Loralyn M Cozy, Bryan R Lanning, Samson Francis, Malcolm E Winkler, Daniel B Kearns, Erin E Carlson
Selective penicillin-binding protein imaging probes reveal substructure in bacterial cell division.
ACS Chem Biol: 2012, 7(10);1746-53
[PubMed:22909777] [WorldCat.org] [DOI] (I p)

Reviews

Truc Do, Julia E Page, Suzanne Walker
Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes.
J Biol Chem: 2020, 295(10);3347-3361
[PubMed:31974163] [WorldCat.org] [DOI] (I p)

Eric Sauvage, Frédéric Kerff, Mohammed Terrak, Juan A Ayala, Paulette Charlier
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.
FEMS Microbiol Rev: 2008, 32(2);234-58
[PubMed:18266856] [WorldCat.org] [DOI] (P p)

André Zapun, Carlos Contreras-Martel, Thierry Vernet
Penicillin-binding proteins and beta-lactam resistance.
FEMS Microbiol Rev: 2008, 32(2);361-85
[PubMed:18248419] [WorldCat.org] [DOI] (P p)

Pauline Macheboeuf, Carlos Contreras-Martel, Viviana Job, Otto Dideberg, Andréa Dessen
Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.
FEMS Microbiol Rev: 2006, 30(5);673-91
[PubMed:16911039] [WorldCat.org] [DOI] (P p)

Dirk-Jan Scheffers, Mariana G Pinho
Bacterial cell wall synthesis: new insights from localization studies.
Microbiol Mol Biol Rev: 2005, 69(4);585-607
[PubMed:16339737] [WorldCat.org] [DOI] (P p)

David L Popham, Kevin D Young
Role of penicillin-binding proteins in bacterial cell morphogenesis.
Curr Opin Microbiol: 2003, 6(6);594-9
[PubMed:14662355] [WorldCat.org] [DOI] (P p)