QcrA

• Description: Rieske factor, menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit), component of the cytochrome bc1 complex
  
  

Gene name	qcrA
Synonyms	bfcA, petC
Essential	no
Product	menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)
Function	respiration
Gene expression levels in SubtiExpress: qcrA
Interactions involving this protein in SubtInteract: QcrA
MW, pI	18 kDa, 6.078
Gene length, protein length	501 bp, 167 aa
Immediate neighbours	qcrB, ypiF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

respiration, membrane proteins

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, ResD regulon

The gene

Basic information

• Locus tag: BSU22560

Database entries

• BsubCyc: BSU22560

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: accD/PCCB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors: contains an iron-sulfur cluster

• Effectors of protein activity:

• Interactions:
  • part of a respiratory supercomplex PubMed
  • QcrA-QcrB-QcrC PubMed

• Localization:
  • cell membrane PubMed
  • delivered to the membrane by the TatAY-TatCY protein secretion system, this depends on prior dusulfide bond formation and co-factor insertion PubMed

Database entries

• BsubCyc: BSU22560

• Structure:

• UniProt: P46911

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: qcrA-qcrB-qcrC PubMed

• Expression browser: qcrA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by casamino acids PubMed
  • induced by oxygen limitation (ResD) PubMed
  • repressed by glucose (5.5-fold) (CcpA) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 204 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1343 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Vivianne J Goosens, Carmine G Monteferrante, Jan Maarten van Dijl
The Tat system of Gram-positive bacteria.
Biochim Biophys Acta: 2014, 1843(8);1698-706
[PubMed:24140208] [WorldCat.org] [DOI] (P p)