qcrB

168

menaquinol:cytochrome c oxidoreductase (cytochrome b subunit), component of the cytochrome bc complex

Locus: BSU_22550

Molecular weight: 25.34 kDa

Isoelectric point: 7.44

Protein length: 224 aa

Gene length: 675 bp

Function: respiration

Product: menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)

Essential: no

Synonyms: qcrB, bfcB, petB

Genomic Context

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Categories containing this gene/protein

Metabolism, Electron transport and ATP synthesis, Respiration, Respiration/ other

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG1290 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, CcpA regulon, AbrB regulon, ResD regulon

Gene

Coordinates: 2,363,913  2,364,587

The protein

Protein family

cytochrome b family (with QcrC, according to UniProt)

Cofactors

heme, covalently bound to Cys-43 PubMed

Structure

1VF5 (PDB) (from Mastigocladus laminosus, 43% identity) PubMed
P46912 (AlphaFold)

Localization

cell membrane PubMed

Expression and Regulation

Operons

Genes: qcrA-qcrB-qcrC

Description: PubMed

Regulation

induced by oxygen limitation (ResD) PubMed

Regulatory mechanism

ResD: activation, PubMed, in resD regulon
CcpA: repression, PubMed, in ccpA regulon
AbrB: repression, PubMed, in abrB regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

BKE22550 (qcrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCAGTCATAAATTTTGTTCA,  downstream forward: _UP4_TAAACTCTTGATCTGCGAAT
BKK22550 (qcrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCAGTCATAAATTTTGTTCA,  downstream forward: _UP4_TAAACTCTTGATCTGCGAAT

References

Reviews

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Original Publications

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