HemZ

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  • Description: coproporphyrinogen III oxidase

Gene name hemZ
Synonyms yhaW, yhaV
Essential no
Product coproporphyrinogen III oxidase
Function heme biosynthesis
Gene expression levels in SubtiExpress: hemZ
MW, pI 57 kDa, 5.899
Gene length, protein length 1503 bp, 501 aa
Immediate neighbours yhaX, khtU
Sequences Protein DNA DNA_with_flanks
Genetic context
HemZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HemZ expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

  • Locus tag: BSU09840

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot)
  • Protein family: anaerobic coproporphyrinogen III oxidase family (according to Swiss-Prot)
  • Paralogous protein(s): hemN

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions during growth in the presence of nitrate (no induction in the absence of terminal electron acceptor) (Fnr, ResD, ArfM) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References