SpoIIIAA

• Description: AAA protease, required for SigG activation
  
  

Gene name	spoIIIAA
Synonyms
Essential	no
Product	AAA protease
Function	activation of SigG
Gene expression levels in SubtiExpress: spoIIIAA
MW, pI	34 kDa, 8.183
Gene length, protein length	921 bp, 307 aa
Immediate neighbours	spoIIIAB, yqhV
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

• Locus tag: BSU24430

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane protein PubMed

Database entries

• Structure:

• UniProt: Q01367

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIIAA-spoIIIAB-spoIIIAC-spoIIIAD-spoIIIAE-spoIIIAF-spoIIIAG-spoIIIAH PubMed

• Expression browser: spoIIIAA PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed during sporulation in the mother cell (SigE) PubMed, switched off by SpoIIID PubMed

• Regulatory mechanism: SpoIIID: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Amy H Camp, Richard Losick
A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.
Mol Microbiol: 2008, 69(2);402-17
[PubMed:18485064] [WorldCat.org] [DOI] (I p)

N Illing, J Errington
The spoIIIA operon of Bacillus subtilis defines a new temporal class of mother-cell-specific sporulation genes under the control of the sigma E form of RNA polymerase.
Mol Microbiol: 1991, 5(8);1927-40
[PubMed:1766372] [WorldCat.org] [DOI] (P p)