Ptb

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  • Description: phosphate butyryltransferase

Gene name ptb
Synonyms yqiS, bkd
Essential no
Product phosphate butyryltransferase
Function utilization of branched-chain keto acids
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis, Ile, Leu, Val
MW, pI 31 kDa, 7.936
Gene length, protein length 897 bp, 299 aa
Immediate neighbours bcd, bkdR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Ptb context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ptb expression.png





























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

BkdR regulon, CodY regulon, SigL regulon

The gene

Basic information

  • Locus tag: BSU24090

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Butanoyl-CoA + phosphate = CoA + butanoylphosphate (according to Swiss-Prot)
  • Protein family: phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1YCO (from Enterococcus faecalis v583, 36% identity, 56% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of isoleucine or valine (BkdR) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References