SpoIIGA

• Description: Pro-SigE protease
  
  

Gene name	spoIIGA
Synonyms
Essential	no
Product	Pro-SigE protease
Function	maturation of SigE
Interactions involving this protein in SubtInteract: SpoIIGA
MW, pI	34 kDa, 8.552
Gene length, protein length	927 bp, 309 aa
Immediate neighbours	bpr, sigE
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

proteolysis, sigma factors and their control, sporulation/ other, membrane proteins

This gene is a member of the following regulons

SinR regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU15310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase U4 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • SpoIIGA protease activity is stimulated by the interaction with SpoIIR in the intermembrane space between the forespore and the mother cell PubMed

• Interactions:
  • SpoIIGA-SigE (Processing) PubMed
  • SpoIIR-SpoIIGA PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P13801

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIGA-sigE-sigG PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • repression by SinR
  • Spo0A: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed