Cofactors

NAD⁺

• Ald
• DhaS
• LplD
• IolG
• GapA
• RocG
• GudB
• Mdh
• NasE
• RhaEW

NADP⁺

• DapB
• GapB
• Icd
• Nos
• YhdN

FAD

• NasB
• NasC
• TrmFO
• YcgT
• YkuN
• YkuP
• YumC

FMN

• YtvA

Flavoproteins

• YacF
• NdhF
• YcgT
• YclD
• YcnD
• YdbM
• YddN
• YdeQ
• YdfE
• YerD
• YetM
• Nos
• HypO
• YfjN

Peter Macheroux, Barbara Kappes, Steven E Ealick
Flavogenomics--a genomic and structural view of flavin-dependent proteins.
FEBS J: 2011, 278(15);2625-34
[PubMed:21635694] [WorldCat.org] [DOI] (I p)

S-adenosyl-L-methionine (SAM)

• YtqB

Biotin

• AccB
• PycA
• YngHB

Calcium

• Abn2

Copper

• CtaC (Cu(A))
• CtaD (Cu(B))
• QoxB (Cu(B))
• Sco

Nickel

• UreA-UreB-UreC (urease), the nickel ion binds the active site in UreC

Mark A Farrugia, Lee Macomber, Robert P Hausinger
Biosynthesis of the urease metallocenter.
J Biol Chem: 2013, 288(19);13178-85
[PubMed:23539618] [WorldCat.org] [DOI] (I p)

Harini Kaluarachchi, Kim C Chan Chung, Deborah B Zamble
Microbial nickel proteins.
Nat Prod Rep: 2010, 27(5);681-94
[PubMed:20442959] [WorldCat.org] [DOI] (I p)

Stephen W Ragsdale
Nickel-based Enzyme Systems.
J Biol Chem: 2009, 284(28);18571-5
[PubMed:19363030] [WorldCat.org] [DOI] (P p)

Manganese

• AlsS
• LplD
• NrdF
• OxdC

dimanganic-tyrosyl radical cofactor

• NrdF

Zinc

• ComFB
• LdcB
• RpmE
• RpmGA
• RpmGB
• RpsN
• SufU

MoCo (molybdenum cofactor, molybdopterin)

• NarG
• NasC

Iron-sulfur cluster

• LeuC
• LeuD
• QcrA
• NarH
• NarG
• NasB
• NasC
• NasD
• NsrR

Heme A

• CtaD

Heme b

• NarI
• Nos

Protoheme IX

• EfeB

Thiamine pyrophosphate, TPP

• Tkt
• AlsS

E1 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase

• PdhA

Lipoic acid

E2 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase

• PdhC
• OdhB
• AcoC
• BkdB

H protein of the glycine cleavage system

• GcvH (also required for LipL-catalyzed octanoyl transfer from AcpA to the E2s)

Pyridoxyl phosphate, PLP

• GabR
• GcvP
• NifS
• NtdA
• SufS
• YlmE

Tetrahydrofalate

• GcvT

Methylene-THF

• TrmFO