Phosphorelay

Parent categories	4. Lifestyles 4.2. Sporulation and Germination
Neighbouring categories	4.2.1. Sporulation proteins 4.2.2. Phosphorelay 4.2.3. Sporulation/ other 4.2.4. Germination
Related categories	two-component systems response regulator aspartate phosphatases phosphoproteins protein kinases and phosphatases
Overview on the categories (Excel file) All genes and their categories (Excel file)

Parent categories	3. Information processing 3.4. Regulation of gene expression
Neighbouring categories	3.4.1. Sigma factors and their control 3.4.2. Transcription factors and their control 3.4.3. Trigger enzymes 3.4.4. RNA binding regulators 3.4.5. Regulators of core metabolism 3.4.6. Transition state regulators 3.4.7. Phosphorelay 3.4.8. Quorum sensing
Related categories	see Table to the right
Overview on the categories (Excel file) All genes and their categories (Excel file)

The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.

The kinases

• KinA (controlled by Sda, KipI, and KipA)
• KinB (controlled by Sda, KbaA, and KapB)
• KinC
• KinD
• KinE

The phosphotransferases

• Spo0F
• Spo0B

The ultimate target

• Spo0A

Phosphatases controlling the phosphorelay (and peptides that modulate their activity)

• Spo0E: dephosphorylation of Spo0A
• YisI: dephosphorylation of Spo0A
• YnzD: dephosphorylation of Spo0A
• RapA, PhrA: dephosphorylation of Spo0F
• RapB: dephosphorylation of Spo0F
• RapE, PhrE: dephosphorylation of Spo0F
• RapH: dephosphorylation of Spo0F

Reviews

Keith Stephenson, James A Hoch
Evolution of signalling in the sporulation phosphorelay.
Mol Microbiol: 2002, 46(2);297-304
[PubMed:12406209] [WorldCat.org] [DOI] (P p)

M Perego, J A Brannigan
Pentapeptide regulation of aspartyl-phosphate phosphatases.
Peptides: 2001, 22(10);1541-7
[PubMed:11587783] [WorldCat.org] [DOI] (P p)

J A Hoch, K I Varughese
Keeping signals straight in phosphorelay signal transduction.
J Bacteriol: 2001, 183(17);4941-9
[PubMed:11489844] [WorldCat.org] [DOI] (P p)

J A Hoch
Two-component and phosphorelay signal transduction.
Curr Opin Microbiol: 2000, 3(2);165-70
[PubMed:10745001] [WorldCat.org] [DOI] (P p)

M Perego
Kinase-phosphatase competition regulates Bacillus subtilis development.
Trends Microbiol: 1998, 6(9);366-70
[PubMed:9778730] [WorldCat.org] [DOI] (P p)

M Perego, P Glaser, J A Hoch
Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis.
Mol Microbiol: 1996, 19(6);1151-7
[PubMed:8730857] [WorldCat.org] [DOI] (P p)

K Trach, D Burbulys, M Strauch, J J Wu, N Dhillon, R Jonas, C Hanstein, P Kallio, M Perego, T Bird
Control of the initiation of sporulation in Bacillus subtilis by a phosphorelay.
Res Microbiol: 1991, 142(7-8);815-23
[PubMed:1664534] [WorldCat.org] [DOI] (P p)

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