Difference between revisions of "MecA"
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| − | * '''Description:''' buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets [[ComK]] to [[ClpC]]-[[ClpP]] degradation machine (in log Phase), inhibits the transcriptional activity of [[Spo0A]]∼P by direct interaction <br/><br/> | + | * '''Description:''' buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets [[ComK]] and [[ComS]] to [[ClpC]]-[[ClpP]] degradation machine (in log Phase), inhibits the transcriptional activity of [[Spo0A]]∼P by direct interaction <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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* '''Structure:''' | * '''Structure:''' | ||
** [http://www.proteopedia.org/wiki/index.php/3jtp 3JTP] (C-terminal domain) {{PubMed|19801546}} | ** [http://www.proteopedia.org/wiki/index.php/3jtp 3JTP] (C-terminal domain) {{PubMed|19801546}} | ||
| − | ** [http://www.rcsb.org/pdb/explore/explore.do?pdbId=3PXG 3PXG] (the [[MecA]]-[[ClpC]] complex) {{PubMed| | + | ** [http://www.rcsb.org/pdb/explore/explore.do?pdbId=3PXG 3PXG], [http://www.rcsb.org/pdb/explore/explore.do?pdbId= 3J3U 3J3U] (the [[MecA]]-[[ClpC]] complex) {{PubMed|23595989}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P37958 P37958] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P37958 P37958] | ||
| Line 141: | Line 141: | ||
=References= | =References= | ||
==Reviews == | ==Reviews == | ||
| − | + | <pubmed> 23375660 23479438,19609260</pubmed> | |
| − | <pubmed> 23375660 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | + | <pubmed>11914365,9000055,17560370,19361434, 9890793,2113920,8817496, , 8412687,11918817, 10447896, 12028382, 8016067, 10361283, 11703662 9535081 19767395 19801546 8016066 19202088 8083167 21368759 23595989 16525504,12598648,21435029</pubmed> | |
| − | <pubmed>11914365,9000055,17560370,19361434, 9890793,2113920,8817496, , 8412687,11918817, 10447896, 12028382, 8016067, 10361283, 11703662 9535081 19767395 19801546 8016066 19202088 8083167 21368759</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:52, 14 June 2013
- Description: buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets ComK and ComS to ClpC-ClpP degradation machine (in log Phase), inhibits the transcriptional activity of Spo0A∼P by direct interaction
| Gene name | mecA |
| Synonyms | |
| Essential | no |
| Product | adaptor protein |
| Function | control of ComK degradation, regulation of competence |
| Gene expression levels in SubtiExpress: mecA | |
| Interactions involving this protein in SubtInteract: MecA | |
| MW, pI | 25 kDa, 4.209 |
| Gene length, protein length | 654 bp, 218 aa |
| Immediate neighbours | yjbE, coiA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
genetic competence, proteolysis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU11520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: mecA family (according to Swiss-Prot)
- Paralogous protein(s): YpbH
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: P37958
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP813 (spc), GP814 (aphA3) both available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
