Difference between revisions of "LpdV"

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|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of branched-chain keto acids
 
|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of branched-chain keto acids
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU24060 lpdV]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24060 lpdV]
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis], [http://subtiwiki.uni-goettingen.de/pathways/ile_val_leu.html Ile, Leu, Val]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis], [http://subtiwiki.uni-goettingen.de/pathways/ile_val_leu.html Ile, Leu, Val]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bkdAA]]'', ''[[buk]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bkdAA]]'', ''[[buk]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14337&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24060 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24060 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24060 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:lpdV_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:lpdV_context.gif]]

Revision as of 13:14, 13 May 2013

  • Description: 2-oxoisovalerate dehydrogenase (E3 subunit, dihydrolipoamide dehydrogenase)

Gene name lpdV
Synonyms yqiV, bkd
Essential no
Product 2-oxoisovalerate dehydrogenase
(E3 subunit, dihydrolipoamide dehydrogenase)
Function utilization of branched-chain keto acids
Gene expression levels in SubtiExpress: lpdV
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis, Ile, Leu, Val
MW, pI 48 kDa, 4.893
Gene length, protein length 1371 bp, 457 aa
Immediate neighbours bkdAA, buk
Sequences Protein DNA Advanced_DNA
Genetic context
LpdV context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LpdV expression.png






























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

BkdR regulon, CodY regulon, SigL regulon

The gene

Basic information

  • Locus tag: BSU24060

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH (according to Swiss-Prot)
  • Protein family: class-I pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2YQU (from Thermus thermophilus (hb8 mutant), 42% identity, 55% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of isoleucine or valine (BkdR) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References