Difference between revisions of "BkdAB"

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|colspan="2" | '''Genetic context''' <br/> [[Image:bkdAB_context.gif]]
 
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bkdAB_2498093_2499076_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:bkdAB_expression.png|500px]]
 
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Revision as of 07:59, 20 April 2012

  • Description: 2-oxoisovalerate dehydrogenase (E1 beta subunit)

Gene name bkdAB
Synonyms bfmBAB, bfmB1b, bkd
Essential no
Product 2-oxoisovalerate dehydrogenase (E1 beta subunit)
Function utilization of branched-chain keto acids
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis, Ile, Leu, Val
MW, pI 35 kDa, 4.791
Gene length, protein length 981 bp, 327 aa
Immediate neighbours bkdB, bkdAA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
BkdAB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
500px






























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

BkdR regulon, CodY regulon, SigL regulon

The gene

Basic information

  • Locus tag: BSU24040

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of isoleucine or valine (BkdR) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References