HemZ

• Description: coproporphyrinogen III oxidase
  
  

Gene name	hemZ
Synonyms	yhaW, yhaV
Essential	no
Product	coproporphyrinogen III oxidase
Function	heme biosynthesis
MW, pI	57 kDa, 5.899
Gene length, protein length	1503 bp, 501 aa
Immediate neighbours	yhaX, yhaU
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

• Locus tag: BSU09840

Expression

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO₂ + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot)

• Protein family: anaerobic coproporphyrinogen III oxidase family (according to Swiss-Prot)

• Paralogous protein(s): hemN

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q796V8

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hemZ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced under anaerobic conditions during growth in the presence of nitrate (no induction in the absence of terminal electron acceptor) (Fnr, ResD, ArfM) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

G Homuth, A Rompf, W Schumann, D Jahn
Transcriptional control of Bacillus subtilis hemN and hemZ.
J Bacteriol: 1999, 181(19);5922-9
[PubMed:10498703] [WorldCat.org] [DOI] (P p)